New silver complexes with mixed thiazolidine and phosphine ligands as highly potent antimalarial and anticancer agents

Nur Rahimah Fitrah Mohd Sofyan, Fariza Juliana Nordin, Mohd Ridzuan Mohd Abd Razak, Syahrina Nur Ain Abdul Halim, Nur Adila Fatin Mohd Khir, Amirrudin Muhammad, Nor Fadilah Rajab, Rozie Sarip

Research output: Contribution to journalArticle

Abstract

Five silver(I) complexes containing a mixed ligand system of phosphine and thiazolidine were successfully synthesized. The structural information of the complexes was assembled using various spectroscopic techniques such as CHN elemental analysis, Fourier transformed infrared (FTIR), 1H, 13C, and 31P{1H} NMR spectroscopy, and thermogravimetric analysis (TGA). A bidentate phosphine ligand acted as a chelating agent which bond to the silver in 1: 2 molar ratios. Meanwhile, thiazolidine was attached to the silver in a 1: 1 molar ratio. The antiplasmodial properties of all synthesized complexes were investigated on chloroquine-resistant P. falciparum parasite via HRP2 assays and cytotoxicity tests on Vero cells. Of all the synthesized complexes, complex 2 showed the highest SI value (more than 12.4) followed by complex 5 (6.6). The potent properties of compounds 2 and 5 were also noted in the in vitro antiproliferative assays involving MDA-MB-231 and MCF-7 breast cancer cell lines as well as HT-29 colon cancer cell line. Complex 2 was selective for MDA-MB-231 cells (GI50 = 1.9 ± 0.3 μM), while complex 5 acted predominantly on breast carcinoma cells (GI50 MDA-MB-231 = 4.7 ± 1.1 μM; MCF-7 = 2.9 ± 0.9 μM) instead of colon carcinoma (HT-29) cells (GI50 = 15.1 ± 1.9 μM).

Original languageEnglish
Article number8395374
JournalJournal of Chemistry
Volume2018
DOIs
Publication statusPublished - 1 Jan 2018

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phosphine
Thiazolidines
Antimalarials
Silver
Antineoplastic Agents
Cells
Ligands
Assays
Chloroquine
Cytotoxicity
Chelating Agents
Nuclear magnetic resonance spectroscopy
Thermogravimetric analysis
Infrared radiation
Chemical analysis

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Mohd Sofyan, N. R. F., Nordin, F. J., Mohd Abd Razak, M. R., Abdul Halim, S. N. A., Mohd Khir, N. A. F., Muhammad, A., ... Sarip, R. (2018). New silver complexes with mixed thiazolidine and phosphine ligands as highly potent antimalarial and anticancer agents. Journal of Chemistry, 2018, [8395374]. https://doi.org/10.1155/2018/8395374

New silver complexes with mixed thiazolidine and phosphine ligands as highly potent antimalarial and anticancer agents. / Mohd Sofyan, Nur Rahimah Fitrah; Nordin, Fariza Juliana; Mohd Abd Razak, Mohd Ridzuan; Abdul Halim, Syahrina Nur Ain; Mohd Khir, Nur Adila Fatin; Muhammad, Amirrudin; Rajab, Nor Fadilah; Sarip, Rozie.

In: Journal of Chemistry, Vol. 2018, 8395374, 01.01.2018.

Research output: Contribution to journalArticle

Mohd Sofyan, NRF, Nordin, FJ, Mohd Abd Razak, MR, Abdul Halim, SNA, Mohd Khir, NAF, Muhammad, A, Rajab, NF & Sarip, R 2018, 'New silver complexes with mixed thiazolidine and phosphine ligands as highly potent antimalarial and anticancer agents', Journal of Chemistry, vol. 2018, 8395374. https://doi.org/10.1155/2018/8395374
Mohd Sofyan NRF, Nordin FJ, Mohd Abd Razak MR, Abdul Halim SNA, Mohd Khir NAF, Muhammad A et al. New silver complexes with mixed thiazolidine and phosphine ligands as highly potent antimalarial and anticancer agents. Journal of Chemistry. 2018 Jan 1;2018. 8395374. https://doi.org/10.1155/2018/8395374
Mohd Sofyan, Nur Rahimah Fitrah ; Nordin, Fariza Juliana ; Mohd Abd Razak, Mohd Ridzuan ; Abdul Halim, Syahrina Nur Ain ; Mohd Khir, Nur Adila Fatin ; Muhammad, Amirrudin ; Rajab, Nor Fadilah ; Sarip, Rozie. / New silver complexes with mixed thiazolidine and phosphine ligands as highly potent antimalarial and anticancer agents. In: Journal of Chemistry. 2018 ; Vol. 2018.
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