New inhibitors of ROS generation and T-cell proliferation from myrtus communis

M. Iqbal Choudhary, Noureen Khan, Manzoor Ahmad, Sammer Yousuf, Hoong Kun Fun, Samreen Soomro, M. Asif, Osman Mesaik Mohammed Ahmed Hassan, Farzana Shaheen

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Phytochemical investigation on Myrtus communis Linn. afforded myrtucommuacetalone (1) with an unprecedented carbon skeleton and a new phloroglucinol-type compound, myrtucommulone M (2), along with four known constituents 3-6. Their structures were established by extensive analyses of NMR and mass spectral data as well as by single-crystal X-ray diffraction studies. These constituents were evaluated for their ability to modulate the immune response, based on their effects on various components of immune system. Compounds 1 and 5 exhibited significant inhibitory effect against nitric oxide (NO) production. Compound 1 also exhibited significant antiproliferative activity (IC50 <0.5 μg/mL) against T-cell proliferation. Myricetin (3) exerted a significant inhibition (IC50 = 1.6 μg/mL) on zymosan-stimulated whole blood phagocytes ROS production. Compounds 1 and 3 were active against PMA-stimulated ROS generation.

Original languageEnglish
Pages (from-to)1862-1865
Number of pages4
JournalOrganic Letters
Volume15
Issue number8
DOIs
Publication statusPublished - 19 Apr 2013
Externally publishedYes

Fingerprint

Myrtus
T-cells
Cell proliferation
inhibitors
Inhibitory Concentration 50
phloroglucinol
Phloroglucinol
Cell Proliferation
T-Lymphocytes
immune systems
Zymosan
Immune system
Phytochemicals
nitric oxide
Phagocytes
musculoskeletal system
Skeleton
X-Ray Diffraction
blood
Immune System

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Choudhary, M. I., Khan, N., Ahmad, M., Yousuf, S., Fun, H. K., Soomro, S., ... Shaheen, F. (2013). New inhibitors of ROS generation and T-cell proliferation from myrtus communis. Organic Letters, 15(8), 1862-1865. https://doi.org/10.1021/ol4002976

New inhibitors of ROS generation and T-cell proliferation from myrtus communis. / Choudhary, M. Iqbal; Khan, Noureen; Ahmad, Manzoor; Yousuf, Sammer; Fun, Hoong Kun; Soomro, Samreen; Asif, M.; Mohammed Ahmed Hassan, Osman Mesaik; Shaheen, Farzana.

In: Organic Letters, Vol. 15, No. 8, 19.04.2013, p. 1862-1865.

Research output: Contribution to journalArticle

Choudhary, MI, Khan, N, Ahmad, M, Yousuf, S, Fun, HK, Soomro, S, Asif, M, Mohammed Ahmed Hassan, OM & Shaheen, F 2013, 'New inhibitors of ROS generation and T-cell proliferation from myrtus communis', Organic Letters, vol. 15, no. 8, pp. 1862-1865. https://doi.org/10.1021/ol4002976
Choudhary MI, Khan N, Ahmad M, Yousuf S, Fun HK, Soomro S et al. New inhibitors of ROS generation and T-cell proliferation from myrtus communis. Organic Letters. 2013 Apr 19;15(8):1862-1865. https://doi.org/10.1021/ol4002976
Choudhary, M. Iqbal ; Khan, Noureen ; Ahmad, Manzoor ; Yousuf, Sammer ; Fun, Hoong Kun ; Soomro, Samreen ; Asif, M. ; Mohammed Ahmed Hassan, Osman Mesaik ; Shaheen, Farzana. / New inhibitors of ROS generation and T-cell proliferation from myrtus communis. In: Organic Letters. 2013 ; Vol. 15, No. 8. pp. 1862-1865.
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