New cyclomyrsinol diterpenes from Euphorbia aellenii with their immunomodulatory effects

Mustafa Ghanadian, M. Iqbal Choudhary, Abdul Majid Ayatollahi, Osman Mesaik Mohammed Ahmed Hassan, Omer Mohamed Abdalla, Suleiman Afsharypour

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Chloroform-acetone extract of the aerial parts of Euphorbia aellenii Rech. f. (Euphorbiaceae) was investigated for its diterpenoidal constituents. This led to the isolation of two new and one known cyclomyrsinol-type diterpenes 1-3. The structures were elucidated on the basis of 1D and 2D 1H and 13C NMR techniques, and in vitro immunomodulatory activity was evaluated by standard proliferation of human peripheral blood lymphocytes. Results showed that all the three compounds were found to inhibit lymphocyte proliferation significantly (p <0.05) at 50 μg/ml concentration. Among them, compound 2 showed more activity against phytohemagglutinin-activated T-cell proliferation with an IC50 of 40.4 ± 9.35 μg/ml.

Original languageEnglish
Pages (from-to)22-29
Number of pages8
JournalJournal of Asian Natural Products Research
Volume15
Issue number1
DOIs
Publication statusPublished - 1 Jan 2013
Externally publishedYes

Fingerprint

Euphorbia
Lymphocytes
Diterpenes
Euphorbiaceae
T-cells
Cell proliferation
Phytohemagglutinins
Chloroform
Acetone
Inhibitory Concentration 50
Blood
Cell Proliferation
Nuclear magnetic resonance
Antennas
T-Lymphocytes
Proton Magnetic Resonance Spectroscopy
Carbon-13 Magnetic Resonance Spectroscopy
In Vitro Techniques

Keywords

  • cyclomyrsinol
  • Euphorbia aellenii
  • Euphorbiaceae
  • immunomodulation

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Ghanadian, M., Choudhary, M. I., Ayatollahi, A. M., Mohammed Ahmed Hassan, O. M., Abdalla, O. M., & Afsharypour, S. (2013). New cyclomyrsinol diterpenes from Euphorbia aellenii with their immunomodulatory effects. Journal of Asian Natural Products Research, 15(1), 22-29. https://doi.org/10.1080/10286020.2012.742073

New cyclomyrsinol diterpenes from Euphorbia aellenii with their immunomodulatory effects. / Ghanadian, Mustafa; Choudhary, M. Iqbal; Ayatollahi, Abdul Majid; Mohammed Ahmed Hassan, Osman Mesaik; Abdalla, Omer Mohamed; Afsharypour, Suleiman.

In: Journal of Asian Natural Products Research, Vol. 15, No. 1, 01.01.2013, p. 22-29.

Research output: Contribution to journalArticle

Ghanadian, M, Choudhary, MI, Ayatollahi, AM, Mohammed Ahmed Hassan, OM, Abdalla, OM & Afsharypour, S 2013, 'New cyclomyrsinol diterpenes from Euphorbia aellenii with their immunomodulatory effects', Journal of Asian Natural Products Research, vol. 15, no. 1, pp. 22-29. https://doi.org/10.1080/10286020.2012.742073
Ghanadian M, Choudhary MI, Ayatollahi AM, Mohammed Ahmed Hassan OM, Abdalla OM, Afsharypour S. New cyclomyrsinol diterpenes from Euphorbia aellenii with their immunomodulatory effects. Journal of Asian Natural Products Research. 2013 Jan 1;15(1):22-29. https://doi.org/10.1080/10286020.2012.742073
Ghanadian, Mustafa ; Choudhary, M. Iqbal ; Ayatollahi, Abdul Majid ; Mohammed Ahmed Hassan, Osman Mesaik ; Abdalla, Omer Mohamed ; Afsharypour, Suleiman. / New cyclomyrsinol diterpenes from Euphorbia aellenii with their immunomodulatory effects. In: Journal of Asian Natural Products Research. 2013 ; Vol. 15, No. 1. pp. 22-29.
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