Abstract
Chloroform-acetone extract of the aerial parts of Euphorbia aellenii Rech. f. (Euphorbiaceae) was investigated for its diterpenoidal constituents. This led to the isolation of two new and one known cyclomyrsinol-type diterpenes 1-3. The structures were elucidated on the basis of 1D and 2D 1H and 13C NMR techniques, and in vitro immunomodulatory activity was evaluated by standard proliferation of human peripheral blood lymphocytes. Results showed that all the three compounds were found to inhibit lymphocyte proliferation significantly (p <0.05) at 50 μg/ml concentration. Among them, compound 2 showed more activity against phytohemagglutinin-activated T-cell proliferation with an IC50 of 40.4 ± 9.35 μg/ml.
| Original language | English |
|---|---|
| Pages (from-to) | 22-29 |
| Number of pages | 8 |
| Journal | Journal of Asian Natural Products Research |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2013 |
| Externally published | Yes |
Fingerprint
Keywords
- cyclomyrsinol
- Euphorbia aellenii
- Euphorbiaceae
- immunomodulation
ASJC Scopus subject areas
- Complementary and alternative medicine
- Molecular Medicine
- Organic Chemistry
- Analytical Chemistry
- Pharmaceutical Science
- Pharmacology
- Drug Discovery
Cite this
New cyclomyrsinol diterpenes from Euphorbia aellenii with their immunomodulatory effects. / Ghanadian, Mustafa; Choudhary, M. Iqbal; Ayatollahi, Abdul Majid; Mohammed Ahmed Hassan, Osman Mesaik; Abdalla, Omer Mohamed; Afsharypour, Suleiman.
In: Journal of Asian Natural Products Research, Vol. 15, No. 1, 01.01.2013, p. 22-29.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New cyclomyrsinol diterpenes from Euphorbia aellenii with their immunomodulatory effects
AU - Ghanadian, Mustafa
AU - Choudhary, M. Iqbal
AU - Ayatollahi, Abdul Majid
AU - Mohammed Ahmed Hassan, Osman Mesaik
AU - Abdalla, Omer Mohamed
AU - Afsharypour, Suleiman
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Chloroform-acetone extract of the aerial parts of Euphorbia aellenii Rech. f. (Euphorbiaceae) was investigated for its diterpenoidal constituents. This led to the isolation of two new and one known cyclomyrsinol-type diterpenes 1-3. The structures were elucidated on the basis of 1D and 2D 1H and 13C NMR techniques, and in vitro immunomodulatory activity was evaluated by standard proliferation of human peripheral blood lymphocytes. Results showed that all the three compounds were found to inhibit lymphocyte proliferation significantly (p <0.05) at 50 μg/ml concentration. Among them, compound 2 showed more activity against phytohemagglutinin-activated T-cell proliferation with an IC50 of 40.4 ± 9.35 μg/ml.
AB - Chloroform-acetone extract of the aerial parts of Euphorbia aellenii Rech. f. (Euphorbiaceae) was investigated for its diterpenoidal constituents. This led to the isolation of two new and one known cyclomyrsinol-type diterpenes 1-3. The structures were elucidated on the basis of 1D and 2D 1H and 13C NMR techniques, and in vitro immunomodulatory activity was evaluated by standard proliferation of human peripheral blood lymphocytes. Results showed that all the three compounds were found to inhibit lymphocyte proliferation significantly (p <0.05) at 50 μg/ml concentration. Among them, compound 2 showed more activity against phytohemagglutinin-activated T-cell proliferation with an IC50 of 40.4 ± 9.35 μg/ml.
KW - cyclomyrsinol
KW - Euphorbia aellenii
KW - Euphorbiaceae
KW - immunomodulation
UR - http://www.scopus.com/inward/record.url?scp=84873608239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873608239&partnerID=8YFLogxK
U2 - 10.1080/10286020.2012.742073
DO - 10.1080/10286020.2012.742073
M3 - Article
C2 - 23281657
AN - SCOPUS:84873608239
VL - 15
SP - 22
EP - 29
JO - Journal of Asian Natural Products Research
JF - Journal of Asian Natural Products Research
SN - 1028-6020
IS - 1
ER -