New alkaloids from Phoebe grandis (Nees) Merr

Khalijah Awang, Mat Ropi Mukhtar, A. Hamid A Hadi, Marc Litaudon, Jalifah Latip, Noor Rain Abdullah

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The alkaloidal extract of the leaves of Phoebe grandis (nees) merr. have provided two new minor alkaloids; phoebegrandine D (1), a proaporphine-tryptamine dimer, and phoebegrandine E (2), an indoloquinolizidine. This is the first report on the occurrence of an indoloquinolizidine in the Phoebe species. The crude extract also exhibited antiplasmodial activity (IC50<8 μg mL-1). The structures of the novel compounds were elucidated by spectroscopic methods, notably 2D NMR and HRMS.

Original languageEnglish
Pages (from-to)567-572
Number of pages6
JournalNatural Product Research
Volume20
Issue number6
DOIs
Publication statusPublished - 20 May 2006

Fingerprint

Phoebe
Saturn
Complex Mixtures
Alkaloids
Dimers
alkaloids
Nuclear magnetic resonance
tryptamine
antimalarials
leaf extracts
Inhibitory Concentration 50
inhibitory concentration 50
extracts
methodology

Keywords

  • Alkaloid
  • NMR
  • Phoebe grandis
  • Phoebegrandine D
  • Phoebegrandine E
  • Proaporphine-tryptamine dimer

ASJC Scopus subject areas

  • Molecular Medicine
  • Plant Science
  • Chemistry(all)
  • Biochemistry

Cite this

Awang, K., Mukhtar, M. R., Hadi, A. H. A., Litaudon, M., Latip, J., & Abdullah, N. R. (2006). New alkaloids from Phoebe grandis (Nees) Merr. Natural Product Research, 20(6), 567-572. https://doi.org/10.1080/14786410500183944

New alkaloids from Phoebe grandis (Nees) Merr. / Awang, Khalijah; Mukhtar, Mat Ropi; Hadi, A. Hamid A; Litaudon, Marc; Latip, Jalifah; Abdullah, Noor Rain.

In: Natural Product Research, Vol. 20, No. 6, 20.05.2006, p. 567-572.

Research output: Contribution to journalArticle

Awang, K, Mukhtar, MR, Hadi, AHA, Litaudon, M, Latip, J & Abdullah, NR 2006, 'New alkaloids from Phoebe grandis (Nees) Merr', Natural Product Research, vol. 20, no. 6, pp. 567-572. https://doi.org/10.1080/14786410500183944
Awang K, Mukhtar MR, Hadi AHA, Litaudon M, Latip J, Abdullah NR. New alkaloids from Phoebe grandis (Nees) Merr. Natural Product Research. 2006 May 20;20(6):567-572. https://doi.org/10.1080/14786410500183944
Awang, Khalijah ; Mukhtar, Mat Ropi ; Hadi, A. Hamid A ; Litaudon, Marc ; Latip, Jalifah ; Abdullah, Noor Rain. / New alkaloids from Phoebe grandis (Nees) Merr. In: Natural Product Research. 2006 ; Vol. 20, No. 6. pp. 567-572.
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