Neutrophil gelatinase-associated lipocalin as an early marker of contrast-induced nephropathy after coronary angiography

Sabah Mohamed Alharazy, Norella Kong, Rashidi Saidin, Abdul Halim Abdul Gafor, Oteh Maskon, Marlyn Mohd, Syed Zulkifli Syed Zakaria

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) was an early predictive biomarker of contrast-induced nephropathy (CIN) in patients with chronic kidney disease (n = 100) undergoing coronary catheterization. Serum creatinine (SCr) levels were measured at baseline, 24 hours, and 48 hours post procedure. Serum NGAL was measured preprocedure, 4 hours, and 24 hours post procedure. The frequency of CIN was 11%. In patients with CIN, SCr achieved significance only at 48 hours (P =.006), whereas serum NGAL increased ≥25% from baseline at 24 hours in 7 of 11 patients with CIN (P =.04) but did not change in the other 4. However, serum NGAL also rose ≥25% in 12 of 89 non-CIN patients. This subgroup could have had "incipient CIN." Serum NGAL delta value at baseline, 24 hours was superior to SCr for early diagnosis of CIN. In conclusion, serum NGAL is an early predictive biomarker for CIN.

Original languageEnglish
Pages (from-to)216-223
Number of pages8
JournalAngiology
Volume65
Issue number3
DOIs
Publication statusPublished - Mar 2014

Fingerprint

Coronary Angiography
Serum
Creatinine
Biomarkers
Lipocalin-2
Chronic Renal Insufficiency
Catheterization
Early Diagnosis

Keywords

  • chronic kidney disease
  • contrast-induced nephropathy
  • coronary catheterization
  • neutrophil gelatinase-associated lipocalin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Neutrophil gelatinase-associated lipocalin as an early marker of contrast-induced nephropathy after coronary angiography. / Alharazy, Sabah Mohamed; Kong, Norella; Saidin, Rashidi; Abdul Gafor, Abdul Halim; Maskon, Oteh; Mohd, Marlyn; Syed Zakaria, Syed Zulkifli.

In: Angiology, Vol. 65, No. 3, 03.2014, p. 216-223.

Research output: Contribution to journalArticle

Alharazy, Sabah Mohamed ; Kong, Norella ; Saidin, Rashidi ; Abdul Gafor, Abdul Halim ; Maskon, Oteh ; Mohd, Marlyn ; Syed Zakaria, Syed Zulkifli. / Neutrophil gelatinase-associated lipocalin as an early marker of contrast-induced nephropathy after coronary angiography. In: Angiology. 2014 ; Vol. 65, No. 3. pp. 216-223.
@article{51f0e9bf4b944ef1ae2af6c8d5e6fee4,
title = "Neutrophil gelatinase-associated lipocalin as an early marker of contrast-induced nephropathy after coronary angiography",
abstract = "We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) was an early predictive biomarker of contrast-induced nephropathy (CIN) in patients with chronic kidney disease (n = 100) undergoing coronary catheterization. Serum creatinine (SCr) levels were measured at baseline, 24 hours, and 48 hours post procedure. Serum NGAL was measured preprocedure, 4 hours, and 24 hours post procedure. The frequency of CIN was 11{\%}. In patients with CIN, SCr achieved significance only at 48 hours (P =.006), whereas serum NGAL increased ≥25{\%} from baseline at 24 hours in 7 of 11 patients with CIN (P =.04) but did not change in the other 4. However, serum NGAL also rose ≥25{\%} in 12 of 89 non-CIN patients. This subgroup could have had {"}incipient CIN.{"} Serum NGAL delta value at baseline, 24 hours was superior to SCr for early diagnosis of CIN. In conclusion, serum NGAL is an early predictive biomarker for CIN.",
keywords = "chronic kidney disease, contrast-induced nephropathy, coronary catheterization, neutrophil gelatinase-associated lipocalin",
author = "Alharazy, {Sabah Mohamed} and Norella Kong and Rashidi Saidin and {Abdul Gafor}, {Abdul Halim} and Oteh Maskon and Marlyn Mohd and {Syed Zakaria}, {Syed Zulkifli}",
year = "2014",
month = "3",
doi = "10.1177/0003319712474947",
language = "English",
volume = "65",
pages = "216--223",
journal = "Angiology",
issn = "0003-3197",
publisher = "SAGE Publications Inc.",
number = "3",

}

TY - JOUR

T1 - Neutrophil gelatinase-associated lipocalin as an early marker of contrast-induced nephropathy after coronary angiography

AU - Alharazy, Sabah Mohamed

AU - Kong, Norella

AU - Saidin, Rashidi

AU - Abdul Gafor, Abdul Halim

AU - Maskon, Oteh

AU - Mohd, Marlyn

AU - Syed Zakaria, Syed Zulkifli

PY - 2014/3

Y1 - 2014/3

N2 - We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) was an early predictive biomarker of contrast-induced nephropathy (CIN) in patients with chronic kidney disease (n = 100) undergoing coronary catheterization. Serum creatinine (SCr) levels were measured at baseline, 24 hours, and 48 hours post procedure. Serum NGAL was measured preprocedure, 4 hours, and 24 hours post procedure. The frequency of CIN was 11%. In patients with CIN, SCr achieved significance only at 48 hours (P =.006), whereas serum NGAL increased ≥25% from baseline at 24 hours in 7 of 11 patients with CIN (P =.04) but did not change in the other 4. However, serum NGAL also rose ≥25% in 12 of 89 non-CIN patients. This subgroup could have had "incipient CIN." Serum NGAL delta value at baseline, 24 hours was superior to SCr for early diagnosis of CIN. In conclusion, serum NGAL is an early predictive biomarker for CIN.

AB - We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) was an early predictive biomarker of contrast-induced nephropathy (CIN) in patients with chronic kidney disease (n = 100) undergoing coronary catheterization. Serum creatinine (SCr) levels were measured at baseline, 24 hours, and 48 hours post procedure. Serum NGAL was measured preprocedure, 4 hours, and 24 hours post procedure. The frequency of CIN was 11%. In patients with CIN, SCr achieved significance only at 48 hours (P =.006), whereas serum NGAL increased ≥25% from baseline at 24 hours in 7 of 11 patients with CIN (P =.04) but did not change in the other 4. However, serum NGAL also rose ≥25% in 12 of 89 non-CIN patients. This subgroup could have had "incipient CIN." Serum NGAL delta value at baseline, 24 hours was superior to SCr for early diagnosis of CIN. In conclusion, serum NGAL is an early predictive biomarker for CIN.

KW - chronic kidney disease

KW - contrast-induced nephropathy

KW - coronary catheterization

KW - neutrophil gelatinase-associated lipocalin

UR - http://www.scopus.com/inward/record.url?scp=84893633192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893633192&partnerID=8YFLogxK

U2 - 10.1177/0003319712474947

DO - 10.1177/0003319712474947

M3 - Article

C2 - 23378196

AN - SCOPUS:84893633192

VL - 65

SP - 216

EP - 223

JO - Angiology

JF - Angiology

SN - 0003-3197

IS - 3

ER -