Neuron-specific splicing

Nor Hakimah Ab Hakim, Burhanuddin Yeop Majlis, Hitoshi Suzuki, Toshifumi Tsukahara

Research output: Contribution to journalReview article

Abstract

During pre-mRNA splicing events, introns are removed from the pre-mRNA, and the remaining exons are connected together to form a single continuous molecule. Alternative splicing is a common mechanism for the regulation of gene expression in eukaryotes. More than 90% of human genes are known to undergo alternative splicing. The most common type of alternative splicing is exon skipping, which is also known as cassette exon. Other known alternative splicing events include alternative 5' splice sites, alternative 3' splice sites, intron retention, and mutually exclusive exons. Alternative splicing events are controlled by regulatory proteins responsible for both positive and negative regulation. In this review, we focus on neuronal splicing regulators and discuss several notable regulators in depth. In addition, we have also included an example of splicing regulation mediated by the RBFox protein family. Lastly, as previous studies have shown that a number of splicing factors are associated with neuronal diseases such as Alzheime's disease (AD) and Autism spectrum disorder (ASD), here we consider their importance in neuronal diseases wherein the underlying mechanisms have yet to be elucidated.

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalBioScience Trends
Volume11
Issue number1
DOIs
Publication statusPublished - 2017

Fingerprint

Alternative Splicing
RNA Splice Sites
Neurons
Exons
RNA Precursors
Introns
Disease
regulation
event
Gene Expression Regulation
Eukaryota
Gene expression
sound storage medium
Proteins
Genes
autism
Molecules

Keywords

  • Alternative splicing
  • Gene regulation
  • RNA splicing
  • Splicing regulator

ASJC Scopus subject areas

  • Health(social science)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hakim, N. H. A., Yeop Majlis, B., Suzuki, H., & Tsukahara, T. (2017). Neuron-specific splicing. BioScience Trends, 11(1), 16-22. https://doi.org/10.5582/bst.2016.01169

Neuron-specific splicing. / Hakim, Nor Hakimah Ab; Yeop Majlis, Burhanuddin; Suzuki, Hitoshi; Tsukahara, Toshifumi.

In: BioScience Trends, Vol. 11, No. 1, 2017, p. 16-22.

Research output: Contribution to journalReview article

Hakim, NHA, Yeop Majlis, B, Suzuki, H & Tsukahara, T 2017, 'Neuron-specific splicing', BioScience Trends, vol. 11, no. 1, pp. 16-22. https://doi.org/10.5582/bst.2016.01169
Hakim, Nor Hakimah Ab ; Yeop Majlis, Burhanuddin ; Suzuki, Hitoshi ; Tsukahara, Toshifumi. / Neuron-specific splicing. In: BioScience Trends. 2017 ; Vol. 11, No. 1. pp. 16-22.
@article{7c029bf75ab54000a3d406f99aaf9d6b,
title = "Neuron-specific splicing",
abstract = "During pre-mRNA splicing events, introns are removed from the pre-mRNA, and the remaining exons are connected together to form a single continuous molecule. Alternative splicing is a common mechanism for the regulation of gene expression in eukaryotes. More than 90{\%} of human genes are known to undergo alternative splicing. The most common type of alternative splicing is exon skipping, which is also known as cassette exon. Other known alternative splicing events include alternative 5' splice sites, alternative 3' splice sites, intron retention, and mutually exclusive exons. Alternative splicing events are controlled by regulatory proteins responsible for both positive and negative regulation. In this review, we focus on neuronal splicing regulators and discuss several notable regulators in depth. In addition, we have also included an example of splicing regulation mediated by the RBFox protein family. Lastly, as previous studies have shown that a number of splicing factors are associated with neuronal diseases such as Alzheime's disease (AD) and Autism spectrum disorder (ASD), here we consider their importance in neuronal diseases wherein the underlying mechanisms have yet to be elucidated.",
keywords = "Alternative splicing, Gene regulation, RNA splicing, Splicing regulator",
author = "Hakim, {Nor Hakimah Ab} and {Yeop Majlis}, Burhanuddin and Hitoshi Suzuki and Toshifumi Tsukahara",
year = "2017",
doi = "10.5582/bst.2016.01169",
language = "English",
volume = "11",
pages = "16--22",
journal = "BioScience Trends",
issn = "1881-7815",
publisher = "International Advancement Center for Medicine & Health Research Co., Ltd. (IACMHR Co., Ltd.)",
number = "1",

}

TY - JOUR

T1 - Neuron-specific splicing

AU - Hakim, Nor Hakimah Ab

AU - Yeop Majlis, Burhanuddin

AU - Suzuki, Hitoshi

AU - Tsukahara, Toshifumi

PY - 2017

Y1 - 2017

N2 - During pre-mRNA splicing events, introns are removed from the pre-mRNA, and the remaining exons are connected together to form a single continuous molecule. Alternative splicing is a common mechanism for the regulation of gene expression in eukaryotes. More than 90% of human genes are known to undergo alternative splicing. The most common type of alternative splicing is exon skipping, which is also known as cassette exon. Other known alternative splicing events include alternative 5' splice sites, alternative 3' splice sites, intron retention, and mutually exclusive exons. Alternative splicing events are controlled by regulatory proteins responsible for both positive and negative regulation. In this review, we focus on neuronal splicing regulators and discuss several notable regulators in depth. In addition, we have also included an example of splicing regulation mediated by the RBFox protein family. Lastly, as previous studies have shown that a number of splicing factors are associated with neuronal diseases such as Alzheime's disease (AD) and Autism spectrum disorder (ASD), here we consider their importance in neuronal diseases wherein the underlying mechanisms have yet to be elucidated.

AB - During pre-mRNA splicing events, introns are removed from the pre-mRNA, and the remaining exons are connected together to form a single continuous molecule. Alternative splicing is a common mechanism for the regulation of gene expression in eukaryotes. More than 90% of human genes are known to undergo alternative splicing. The most common type of alternative splicing is exon skipping, which is also known as cassette exon. Other known alternative splicing events include alternative 5' splice sites, alternative 3' splice sites, intron retention, and mutually exclusive exons. Alternative splicing events are controlled by regulatory proteins responsible for both positive and negative regulation. In this review, we focus on neuronal splicing regulators and discuss several notable regulators in depth. In addition, we have also included an example of splicing regulation mediated by the RBFox protein family. Lastly, as previous studies have shown that a number of splicing factors are associated with neuronal diseases such as Alzheime's disease (AD) and Autism spectrum disorder (ASD), here we consider their importance in neuronal diseases wherein the underlying mechanisms have yet to be elucidated.

KW - Alternative splicing

KW - Gene regulation

KW - RNA splicing

KW - Splicing regulator

UR - http://www.scopus.com/inward/record.url?scp=85014435502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014435502&partnerID=8YFLogxK

U2 - 10.5582/bst.2016.01169

DO - 10.5582/bst.2016.01169

M3 - Review article

C2 - 28049883

AN - SCOPUS:85014435502

VL - 11

SP - 16

EP - 22

JO - BioScience Trends

JF - BioScience Trends

SN - 1881-7815

IS - 1

ER -