Neurodevelopmental outcome of newborns with persistent pulmonary hypertension

Rohana Jaafar, Nem Yun Boo, Viji Chandran, Rajini Sarvananthan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Developmental disabilities have been reported in infants with persistent pulmonary hypertension of the newborn (PPHN) treated with inhaled nitric oxide (INO) or intravenous magnesium sulphate (MgSO4) and/or extracorporeal membrane oxygenation. This paper reports the rate of developmental disabilities at 2 years of age in a cohort of survivors of PPHN treated with INO, MgSO4, or both during the neonatal period. Methods: Sixteen survivors of PPHN were prospectively followed up. These infants were treated with intravenous MgSO4 and/or INO during the neonatal period. Neurodevelopmental assessment was carried out at 2 years of age using the Bayley Scales of Infant Development 2nd Edition by a developmental psychologist. Eleven (68.8%) infants completed the 2-year follow-up. Results: The median mental developmental index (MDI) and physical developmental index scores were 85 (interquartile range, IQR = 27) and 87 (IQR = 33), respectively. Two infants (18.2%) had developmental disability (MDI scores <70). Conclusion: Survivors of PPHN are at risk of developmental disabilities. Early intervention programme and long-term follow-up should be integrated in the management of these infants.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalMalaysian Journal of Medical Sciences
Volume18
Issue number4
Publication statusPublished - Oct 2011

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Persistent Fetal Circulation Syndrome
Developmental Disabilities
Survivors
Nitric Oxide
Magnesium Sulfate
Extracorporeal Membrane Oxygenation
Child Development
Psychology

Keywords

  • Developmental disabilities
  • Magnesium sulphate
  • Neurology
  • Nitric oxide
  • Persistent pulmonary hypertension of newborn

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neurodevelopmental outcome of newborns with persistent pulmonary hypertension. / Jaafar, Rohana; Boo, Nem Yun; Chandran, Viji; Sarvananthan, Rajini.

In: Malaysian Journal of Medical Sciences, Vol. 18, No. 4, 10.2011, p. 57-61.

Research output: Contribution to journalArticle

Jaafar, Rohana ; Boo, Nem Yun ; Chandran, Viji ; Sarvananthan, Rajini. / Neurodevelopmental outcome of newborns with persistent pulmonary hypertension. In: Malaysian Journal of Medical Sciences. 2011 ; Vol. 18, No. 4. pp. 57-61.
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