Neurodevelopmental Outcome of Malaysian Very Low Birth Weight Infants

Predictive Value of Cranial Ultrasound Appearances

L. C. Ong, N. Y. Boo, V. Chandran, A. Zulfiqar, Siti Zamratol Mai Sarah Mukari, L. Allison, S. L. Teoh, M. K. Nyein, M. S. Lye

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of the study was to determine the predictive value of cranial ultrasound scans done in the neonatal period for neurodevelopmental outcome of the Malaysian very low birthweight (VLBW, <1500 grams) infants assessed at 12 months of corrected age. Of the 101 infants studied, 68 (67.3%) were neurodevelopmentally normal at one year of age, 18 (17.8%) had major and 15 (14.9%) had minor neurodevelopmental impairment. Neurodevelopmental outcome was normal in 66/88 (75.0%) infants who did not have severe intraventricular haemorrhage (IVH) or periventricular intraparenchymal echodensities (PVE) in the first week of life, and in 57/73 (78.1%) with uncomplicated scans at discharge. In contrast, 11/13 (84.6%) with parenchymal echodensities or severe intraventricular bleed in the early neonatal period and 17/28 (60.7%) with complicated scans at discharge had adverse sequelae. There was a significant association between lesions seen on cranial ultrasound in the neonatal period and subsequent neurodevelopmental impairment. Late neonatal ultrasound scans appear to be a better predictor of short-term neurodevelopmental outcome than early scans.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalSingapore Medical Journal
Volume38
Issue number3
Publication statusPublished - Mar 1997

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Very Low Birth Weight Infant
Hemorrhage

Keywords

  • Cranial ultrasound
  • Intraventricular haemorrhage (IVH)
  • Malaysian
  • Neurodevelopmental outcome
  • Very low birthweight infants (VLBW)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neurodevelopmental Outcome of Malaysian Very Low Birth Weight Infants : Predictive Value of Cranial Ultrasound Appearances. / Ong, L. C.; Boo, N. Y.; Chandran, V.; Zulfiqar, A.; Mukari, Siti Zamratol Mai Sarah; Allison, L.; Teoh, S. L.; Nyein, M. K.; Lye, M. S.

In: Singapore Medical Journal, Vol. 38, No. 3, 03.1997, p. 108-111.

Research output: Contribution to journalArticle

Ong, LC, Boo, NY, Chandran, V, Zulfiqar, A, Mukari, SZMS, Allison, L, Teoh, SL, Nyein, MK & Lye, MS 1997, 'Neurodevelopmental Outcome of Malaysian Very Low Birth Weight Infants: Predictive Value of Cranial Ultrasound Appearances', Singapore Medical Journal, vol. 38, no. 3, pp. 108-111.
Ong, L. C. ; Boo, N. Y. ; Chandran, V. ; Zulfiqar, A. ; Mukari, Siti Zamratol Mai Sarah ; Allison, L. ; Teoh, S. L. ; Nyein, M. K. ; Lye, M. S. / Neurodevelopmental Outcome of Malaysian Very Low Birth Weight Infants : Predictive Value of Cranial Ultrasound Appearances. In: Singapore Medical Journal. 1997 ; Vol. 38, No. 3. pp. 108-111.
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