Neonatal herpes simplex virus type-1 central nervous system disease with acute retinal necrosis

Choong Yi Fong, Aye Mya Min Aye, Mohammadreza Peyman, Norazlin Kamal Nor, Subrayan Visvaraja, Iqbal Tajunisah, Lai Choo Ong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report a case of neonatal herpes simplex virus (HSV)-1 central nervous system disease with bilateral acute retinal necrosis (ARN). An infant was presented at 17 days of age with focal seizures. Cerebrospinal fluid polymerase chain reaction was positive for HSV-1 and brain magnetic resonance imaging showed cerebritis. While receiving intravenous acyclovir therapy, the infant developed ARN with vitreous fluid polymerase chain reaction positive for HSV-1 necessitating intravitreal foscarnet therapy. This is the first reported neonatal ARN secondary to HSV-1 and the first ARN case presenting without external ocular or cutaneous signs. Our report highlights that infants with neonatal HSV central nervous system disease should undergo a thorough ophthalmological evaluation to facilitate prompt diagnosis and immediate treatment of this rapidly progressive sight-threatening disease.

Original languageEnglish
Pages (from-to)424-426
Number of pages3
JournalPediatric Infectious Disease Journal
Volume33
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Acute Retinal Necrosis Syndrome
Central Nervous System Diseases
Human Herpesvirus 1
Foscarnet
Polymerase Chain Reaction
Acyclovir
Simplexvirus
Cerebrospinal Fluid
Seizures
Therapeutics
Magnetic Resonance Imaging
Skin
Neonatal herpes
Brain

Keywords

  • Acute retinal necrosis
  • Central nervous system
  • Herpes simplex virus
  • Neonate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Neonatal herpes simplex virus type-1 central nervous system disease with acute retinal necrosis. / Fong, Choong Yi; Aye, Aye Mya Min; Peyman, Mohammadreza; Kamal Nor, Norazlin; Visvaraja, Subrayan; Tajunisah, Iqbal; Ong, Lai Choo.

In: Pediatric Infectious Disease Journal, Vol. 33, No. 4, 2014, p. 424-426.

Research output: Contribution to journalArticle

Fong, Choong Yi ; Aye, Aye Mya Min ; Peyman, Mohammadreza ; Kamal Nor, Norazlin ; Visvaraja, Subrayan ; Tajunisah, Iqbal ; Ong, Lai Choo. / Neonatal herpes simplex virus type-1 central nervous system disease with acute retinal necrosis. In: Pediatric Infectious Disease Journal. 2014 ; Vol. 33, No. 4. pp. 424-426.
@article{08b40c3a9e1640c29034392730995125,
title = "Neonatal herpes simplex virus type-1 central nervous system disease with acute retinal necrosis",
abstract = "We report a case of neonatal herpes simplex virus (HSV)-1 central nervous system disease with bilateral acute retinal necrosis (ARN). An infant was presented at 17 days of age with focal seizures. Cerebrospinal fluid polymerase chain reaction was positive for HSV-1 and brain magnetic resonance imaging showed cerebritis. While receiving intravenous acyclovir therapy, the infant developed ARN with vitreous fluid polymerase chain reaction positive for HSV-1 necessitating intravitreal foscarnet therapy. This is the first reported neonatal ARN secondary to HSV-1 and the first ARN case presenting without external ocular or cutaneous signs. Our report highlights that infants with neonatal HSV central nervous system disease should undergo a thorough ophthalmological evaluation to facilitate prompt diagnosis and immediate treatment of this rapidly progressive sight-threatening disease.",
keywords = "Acute retinal necrosis, Central nervous system, Herpes simplex virus, Neonate",
author = "Fong, {Choong Yi} and Aye, {Aye Mya Min} and Mohammadreza Peyman and {Kamal Nor}, Norazlin and Subrayan Visvaraja and Iqbal Tajunisah and Ong, {Lai Choo}",
year = "2014",
doi = "10.1097/INF.0000000000000137",
language = "English",
volume = "33",
pages = "424--426",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Neonatal herpes simplex virus type-1 central nervous system disease with acute retinal necrosis

AU - Fong, Choong Yi

AU - Aye, Aye Mya Min

AU - Peyman, Mohammadreza

AU - Kamal Nor, Norazlin

AU - Visvaraja, Subrayan

AU - Tajunisah, Iqbal

AU - Ong, Lai Choo

PY - 2014

Y1 - 2014

N2 - We report a case of neonatal herpes simplex virus (HSV)-1 central nervous system disease with bilateral acute retinal necrosis (ARN). An infant was presented at 17 days of age with focal seizures. Cerebrospinal fluid polymerase chain reaction was positive for HSV-1 and brain magnetic resonance imaging showed cerebritis. While receiving intravenous acyclovir therapy, the infant developed ARN with vitreous fluid polymerase chain reaction positive for HSV-1 necessitating intravitreal foscarnet therapy. This is the first reported neonatal ARN secondary to HSV-1 and the first ARN case presenting without external ocular or cutaneous signs. Our report highlights that infants with neonatal HSV central nervous system disease should undergo a thorough ophthalmological evaluation to facilitate prompt diagnosis and immediate treatment of this rapidly progressive sight-threatening disease.

AB - We report a case of neonatal herpes simplex virus (HSV)-1 central nervous system disease with bilateral acute retinal necrosis (ARN). An infant was presented at 17 days of age with focal seizures. Cerebrospinal fluid polymerase chain reaction was positive for HSV-1 and brain magnetic resonance imaging showed cerebritis. While receiving intravenous acyclovir therapy, the infant developed ARN with vitreous fluid polymerase chain reaction positive for HSV-1 necessitating intravitreal foscarnet therapy. This is the first reported neonatal ARN secondary to HSV-1 and the first ARN case presenting without external ocular or cutaneous signs. Our report highlights that infants with neonatal HSV central nervous system disease should undergo a thorough ophthalmological evaluation to facilitate prompt diagnosis and immediate treatment of this rapidly progressive sight-threatening disease.

KW - Acute retinal necrosis

KW - Central nervous system

KW - Herpes simplex virus

KW - Neonate

UR - http://www.scopus.com/inward/record.url?scp=84897020779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897020779&partnerID=8YFLogxK

U2 - 10.1097/INF.0000000000000137

DO - 10.1097/INF.0000000000000137

M3 - Article

VL - 33

SP - 424

EP - 426

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 4

ER -