Naturally occurring immunomodulators with antitumor activity

An insight on their mechanisms of action

Shimaa Ibrahim Abdelmonym Mohamed, Ibrahim Jantan, Md Areeful Haque

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Natural products with immunomodulatory activity are widely used in treatment of many diseases including autoimmune diseases, inflammatory disorders in addition to cancer. They gained a great interest in the last decades as therapeutic agents since they provide inexpensive and less toxic products than the synthetic chemotherapeutic agents. Immunomodulators are the agents that have the ability to boost or suppress the host defense response that can be used as a prophylaxis as well as in combination with other therapeutic modalities. The anticancer activity of these immunomodulators is due to their anti-inflammatory, antioxidant, and induction of apoptosis, anti-angiogenesis, and anti-metastasis effect. These natural immunomodulators such as genistein, curcumin, and resveratrol can be used as prophylaxis against the initiation of cancer besides the inhibition of tumor growth and proliferation. Whereas, immunostimulants can elicit and activate humoral and cell-mediated immune responses against the tumor that facilitate the recognition and destruction of the already existing tumor. This review represents the recent studies on various natural immunomodulators with antitumor effects. We have focused on the relationship between their anticancer activity and immunomodulatory mechanisms. The mechanisms of action of various immunomodulators such as polyphenolic compounds, flavonoids, organosulfur compounds, capsaicin, vinca alkaloids, bromelain, betulinic acid and zerumbone, the affected cancerous cell lines in addition to the targeted molecules and transcriptional pathways have been review and critically analyzed.

Original languageEnglish
Pages (from-to)291-304
Number of pages14
JournalInternational Immunopharmacology
Volume50
DOIs
Publication statusPublished - 1 Sep 2017

Fingerprint

Immunologic Factors
Neoplasms
Bromelains
Vinca Alkaloids
Immunologic Adjuvants
Curcumin
Genistein
Poisons
Capsaicin
Biological Products
Flavonoids
Autoimmune Diseases
Anti-Inflammatory Agents
Antioxidants
Apoptosis
Neoplasm Metastasis
Cell Line
Therapeutics
Growth

Keywords

  • Anti-inflammatory
  • Antioxidant
  • Apoptosis
  • Cancer
  • Natural immunomodulators

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Naturally occurring immunomodulators with antitumor activity : An insight on their mechanisms of action. / Mohamed, Shimaa Ibrahim Abdelmonym; Jantan, Ibrahim; Haque, Md Areeful.

In: International Immunopharmacology, Vol. 50, 01.09.2017, p. 291-304.

Research output: Contribution to journalReview article

Mohamed, Shimaa Ibrahim Abdelmonym ; Jantan, Ibrahim ; Haque, Md Areeful. / Naturally occurring immunomodulators with antitumor activity : An insight on their mechanisms of action. In: International Immunopharmacology. 2017 ; Vol. 50. pp. 291-304.
@article{dbe065da7fa640e4ab68e6846d09e62e,
title = "Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action",
abstract = "Natural products with immunomodulatory activity are widely used in treatment of many diseases including autoimmune diseases, inflammatory disorders in addition to cancer. They gained a great interest in the last decades as therapeutic agents since they provide inexpensive and less toxic products than the synthetic chemotherapeutic agents. Immunomodulators are the agents that have the ability to boost or suppress the host defense response that can be used as a prophylaxis as well as in combination with other therapeutic modalities. The anticancer activity of these immunomodulators is due to their anti-inflammatory, antioxidant, and induction of apoptosis, anti-angiogenesis, and anti-metastasis effect. These natural immunomodulators such as genistein, curcumin, and resveratrol can be used as prophylaxis against the initiation of cancer besides the inhibition of tumor growth and proliferation. Whereas, immunostimulants can elicit and activate humoral and cell-mediated immune responses against the tumor that facilitate the recognition and destruction of the already existing tumor. This review represents the recent studies on various natural immunomodulators with antitumor effects. We have focused on the relationship between their anticancer activity and immunomodulatory mechanisms. The mechanisms of action of various immunomodulators such as polyphenolic compounds, flavonoids, organosulfur compounds, capsaicin, vinca alkaloids, bromelain, betulinic acid and zerumbone, the affected cancerous cell lines in addition to the targeted molecules and transcriptional pathways have been review and critically analyzed.",
keywords = "Anti-inflammatory, Antioxidant, Apoptosis, Cancer, Natural immunomodulators",
author = "Mohamed, {Shimaa Ibrahim Abdelmonym} and Ibrahim Jantan and Haque, {Md Areeful}",
year = "2017",
month = "9",
day = "1",
doi = "10.1016/j.intimp.2017.07.010",
language = "English",
volume = "50",
pages = "291--304",
journal = "International Immunopharmacology",
issn = "1567-5769",
publisher = "Elsevier",

}

TY - JOUR

T1 - Naturally occurring immunomodulators with antitumor activity

T2 - An insight on their mechanisms of action

AU - Mohamed, Shimaa Ibrahim Abdelmonym

AU - Jantan, Ibrahim

AU - Haque, Md Areeful

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Natural products with immunomodulatory activity are widely used in treatment of many diseases including autoimmune diseases, inflammatory disorders in addition to cancer. They gained a great interest in the last decades as therapeutic agents since they provide inexpensive and less toxic products than the synthetic chemotherapeutic agents. Immunomodulators are the agents that have the ability to boost or suppress the host defense response that can be used as a prophylaxis as well as in combination with other therapeutic modalities. The anticancer activity of these immunomodulators is due to their anti-inflammatory, antioxidant, and induction of apoptosis, anti-angiogenesis, and anti-metastasis effect. These natural immunomodulators such as genistein, curcumin, and resveratrol can be used as prophylaxis against the initiation of cancer besides the inhibition of tumor growth and proliferation. Whereas, immunostimulants can elicit and activate humoral and cell-mediated immune responses against the tumor that facilitate the recognition and destruction of the already existing tumor. This review represents the recent studies on various natural immunomodulators with antitumor effects. We have focused on the relationship between their anticancer activity and immunomodulatory mechanisms. The mechanisms of action of various immunomodulators such as polyphenolic compounds, flavonoids, organosulfur compounds, capsaicin, vinca alkaloids, bromelain, betulinic acid and zerumbone, the affected cancerous cell lines in addition to the targeted molecules and transcriptional pathways have been review and critically analyzed.

AB - Natural products with immunomodulatory activity are widely used in treatment of many diseases including autoimmune diseases, inflammatory disorders in addition to cancer. They gained a great interest in the last decades as therapeutic agents since they provide inexpensive and less toxic products than the synthetic chemotherapeutic agents. Immunomodulators are the agents that have the ability to boost or suppress the host defense response that can be used as a prophylaxis as well as in combination with other therapeutic modalities. The anticancer activity of these immunomodulators is due to their anti-inflammatory, antioxidant, and induction of apoptosis, anti-angiogenesis, and anti-metastasis effect. These natural immunomodulators such as genistein, curcumin, and resveratrol can be used as prophylaxis against the initiation of cancer besides the inhibition of tumor growth and proliferation. Whereas, immunostimulants can elicit and activate humoral and cell-mediated immune responses against the tumor that facilitate the recognition and destruction of the already existing tumor. This review represents the recent studies on various natural immunomodulators with antitumor effects. We have focused on the relationship between their anticancer activity and immunomodulatory mechanisms. The mechanisms of action of various immunomodulators such as polyphenolic compounds, flavonoids, organosulfur compounds, capsaicin, vinca alkaloids, bromelain, betulinic acid and zerumbone, the affected cancerous cell lines in addition to the targeted molecules and transcriptional pathways have been review and critically analyzed.

KW - Anti-inflammatory

KW - Antioxidant

KW - Apoptosis

KW - Cancer

KW - Natural immunomodulators

UR - http://www.scopus.com/inward/record.url?scp=85024370614&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85024370614&partnerID=8YFLogxK

U2 - 10.1016/j.intimp.2017.07.010

DO - 10.1016/j.intimp.2017.07.010

M3 - Review article

VL - 50

SP - 291

EP - 304

JO - International Immunopharmacology

JF - International Immunopharmacology

SN - 1567-5769

ER -