Natural Polyphenols in the Treatment of Alzheimer's Disease

Syed Badrul Syarifah-Noratiqah, Isa Naina Mohamed, Mohamed S. Zulfarina, Qodriyah Mohd Saad

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Neurodegenerative disease is an incurable disease which involves the degeneration or death of the nerve cells. Alzheimer's Disease (AD) is a neurodegenerative disease discovered in 1906 by Alois Alzheimer, a German clinical psychiatrist and neuroanatomist. The main pathological hallmarks of this disease are the formation of extracellular amyloid β (Aβ) plaques and intracellular neurofibrillary tangle (NFT). The accumulation of the amyloid protein aggregates in the brain of AD patients leads to oxidative stress and inflammation. Other postulated reasons for the development of this disease are cholinergic depletion and excessive glutamatergic neurotransmission. The current drugs approved and marketed for the treatment of AD are cholinesterase inhibitors (ChEIs) and N-methyl-Daspartate (NMDA) receptor antagonists. The function of ChEIs is to avoid cholinergic depletion; whereas the function of NMDA receptor antagonist is to block excessive glutamatergic neurotransmission. Unfortunately, the current drugs prescribed for AD show only modest improvement in terms of symptomatic relief and delay the progression of the disease. This review will discuss about several polyphenolic compounds as potential natural treatment options for AD. Three compounds are highlighted in this review - Curcumin (Cur), Resveratrol (Rsv) and Epigallocatechin-3- gallate (EGCG). These compounds have huge potential for AD treatment, especially due to their low frequency of adverse events. However, the current conventional pharmaceutical drugs remain as the mainstay of treatment for AD.

Original languageEnglish
Pages (from-to)927-937
Number of pages11
JournalCurrent drug targets
Volume19
Issue number8
DOIs
Publication statusPublished - 1 Jan 2018

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Polyphenols
Alzheimer Disease
Cholinesterase Inhibitors
Synaptic Transmission
Neurodegenerative Diseases
Pharmaceutical Preparations
Cholinergic Agents
Therapeutics
Neurodegenerative diseases
Amyloidogenic Proteins
Neurofibrillary Tangles
Curcumin
Amyloid Plaques
Brain Diseases
Polyphenolic compounds
Psychiatry
Disease Progression
Oxidative Stress
Oxidative stress
Inflammation

Keywords

  • Cholinesterase inhibitors
  • curcumin
  • epigallocatechin-3-gallate
  • N-methyl-D-aspartate
  • neurodegenerative disease
  • polyphenolic compounds
  • resveratrol.

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Natural Polyphenols in the Treatment of Alzheimer's Disease. / Syarifah-Noratiqah, Syed Badrul; Naina Mohamed, Isa; Zulfarina, Mohamed S.; Mohd Saad, Qodriyah.

In: Current drug targets, Vol. 19, No. 8, 01.01.2018, p. 927-937.

Research output: Contribution to journalArticle

Syarifah-Noratiqah, Syed Badrul ; Naina Mohamed, Isa ; Zulfarina, Mohamed S. ; Mohd Saad, Qodriyah. / Natural Polyphenols in the Treatment of Alzheimer's Disease. In: Current drug targets. 2018 ; Vol. 19, No. 8. pp. 927-937.
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