Nasopharyngeal carcinoma in dermatomyositis patients

A 10-year retrospective review in Hospital Selayang, Malaysia

J. W. Teoh, Mohd. Razif Mohamad Yunus, Faridah Hassan, Norazmi Ghazali, Zainal A Z Abidin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aim: The objective of our review is to investigate the association between dermatomyositis patients and nasopharyngeal carcinoma (NPC) together with the clinical presentation of the patients and their management in otorhinolaryngology. Background: NPC is a malignant disease with good prognosis on early diagnosis. However, the relationship between the dermatomyositis and NPC and its management is not well defined. Materials and methods: A 10-year retrospective review of case records of 21 dermatomyositis patients seen in Otorhinolaryngology Department of Hospital Selayang from January 2000 to November 2010. Results: These patients ranged from 19 to 74 years old and a total of 8 (38%) out of 21 adults with dermatomyositis were detected to have malignancy. Five out of 8 patients had NPC (62.5%). The mean age of patients with NPC and dermatomyositis was 48 years. NPC is diagnosed in 4 out of 5 patients (80%) in the first year of diagnosis of dermatomyositis. The clinical findings of the examination of nasopharynx ranged from hyperemia to exophytic nasopharyngeal mass. Histologically, it is only related to NPC of WHO types II and III. Conclusions: There is a strong relationship between dermatomyositis and malignancy, especially NPC. Clinicians should have a high index of suspicion for malignancy in all dermatomyositis patients. Rigid nasoendoscopies and biopsies, serum Epstein-Barr viral capsid IgA antibody and imaging studies are helpful in detecting NPC in dermatomyositis patients.

Original languageEnglish
Pages (from-to)332-336
Number of pages5
JournalReports of Practical Oncology and Radiotherapy
Volume19
Issue number5
DOIs
Publication statusPublished - 28 Jun 2012

Fingerprint

Dermatomyositis
Malaysia
antineoplaston A10
Otolaryngology
Nasopharyngeal carcinoma
Neoplasms
Nasopharynx
Capsid
Hospital Departments
Hyperemia
Immunoglobulin A
Early Diagnosis
Biopsy
Antibodies

Keywords

  • Dermatomyositis
  • Epstein-Barr viral capsid IgA
  • Nasopharyngeal carcinoma
  • Paraneoplastic
  • WHO histology

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Nasopharyngeal carcinoma in dermatomyositis patients : A 10-year retrospective review in Hospital Selayang, Malaysia. / Teoh, J. W.; Mohamad Yunus, Mohd. Razif; Hassan, Faridah; Ghazali, Norazmi; Abidin, Zainal A Z.

In: Reports of Practical Oncology and Radiotherapy, Vol. 19, No. 5, 28.06.2012, p. 332-336.

Research output: Contribution to journalArticle

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