Nasopharyngeal carcinoma

Mazita Ami, Salina Husain, Primuharsa Putra Sabir H. Atkar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nasopharyngeal carcinoma is a tumour affecting the nasopharynx commonly arising from the fossa of Rosenmüller and less frequently the posterior wall and roof of the nasopharynx. It has a high incidence amongst the southern Chinese particularly those of the Guangdong Province, Hong Kong and Taiwan. The uniqueness of this tumour is that it has known multifactorial causes with interplay between genetic and environmental factors. The frequent clinical presentation of this disease is asymptomatic neck mass or unilateral ear fullness. Cranial neuropathy may also occur due to the close proximity of the nasopharynx to the base of skull. Nasal endoscopic examination usually reveals an exophytic mass in the nasopharynx or a non suspicious submucosal mass. In less than 10% of cases no mass can be discerned in the nasopharynx. The diagnosis is often confirmed by biopsy. There are three main histopathological subtypes of nasopharyngeal carcinoma; keratinizing squamous cell carcinoma, non keratinizing carcinoma and undifferentiated carcinoma (WHO classification). Treatment of this tumour is mainly radiotherapy or chemoradiotherapy depending on the tumour staging. Surgical treatment of patients with nasopharyngeal carcinoma has a role but with specific indications. In this chapter we review on the latest in nasopharyngeal carcinoma with regards to its pathophysiology and treatment.

Original languageEnglish
Title of host publicationNose and Viral Cancer
Subtitle of host publicationEtiology, Pathogenesis and Treatment
PublisherNova Science Publishers, Inc.
Pages395-418
Number of pages24
ISBN (Electronic)9781617618710
ISBN (Print)9781607417354
Publication statusPublished - 1 Jan 2010

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Nasopharynx
Carcinoma
Cranial Nerve Diseases
Asymptomatic Diseases
Neoplasms
Neoplasm Staging
Skull Base
Hong Kong
Chemoradiotherapy
Taiwan
Nose
Ear
Squamous Cell Carcinoma
Neck
Radiotherapy
Therapeutics
Nasopharyngeal carcinoma
Biopsy
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ami, M., Husain, S., & Atkar, P. P. S. H. (2010). Nasopharyngeal carcinoma. In Nose and Viral Cancer: Etiology, Pathogenesis and Treatment (pp. 395-418). Nova Science Publishers, Inc..

Nasopharyngeal carcinoma. / Ami, Mazita; Husain, Salina; Atkar, Primuharsa Putra Sabir H.

Nose and Viral Cancer: Etiology, Pathogenesis and Treatment. Nova Science Publishers, Inc., 2010. p. 395-418.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ami, M, Husain, S & Atkar, PPSH 2010, Nasopharyngeal carcinoma. in Nose and Viral Cancer: Etiology, Pathogenesis and Treatment. Nova Science Publishers, Inc., pp. 395-418.
Ami M, Husain S, Atkar PPSH. Nasopharyngeal carcinoma. In Nose and Viral Cancer: Etiology, Pathogenesis and Treatment. Nova Science Publishers, Inc. 2010. p. 395-418
Ami, Mazita ; Husain, Salina ; Atkar, Primuharsa Putra Sabir H. / Nasopharyngeal carcinoma. Nose and Viral Cancer: Etiology, Pathogenesis and Treatment. Nova Science Publishers, Inc., 2010. pp. 395-418
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