Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art

Zahid Hussain, Hnin Ei Thu, Shiow Fern Ng, Shahzeb Khan, Haliza Katas

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

Wound healing is a multifarious and vibrant process of replacing devitalized and damaged cellular structures, leading to restoration of the skin's barrier function, re-establishment of tissue integrity, and maintenance of the internal homeostasis. Curcumin (CUR) and its analogs have gained widespread recognition due to their remarkable anti-inflammatory, anti-infective, anticancer, immunomodulatory, antioxidant, and wound healing activities. However, their pharmaceutical significance is limited due to inherent hydrophobic nature, poor water solubility, low bioavailability, chemical instability, rapid metabolism and short half-life. Owing to their pharmaceutical limitations, newer strategies have been attempted in recent years aiming to mitigate problems related to the effective delivery of curcumanoids and to improve their wound healing potential. These advanced strategies include nanovesicles, polymeric micelles, conventional liposomes and hyalurosomes, nanocomposite hydrogels, electrospun nanofibers, nanohybrid scaffolds, nanoconjugates, nanostructured lipid carriers (NLCs), nanoemulsion, nanodispersion, and polymeric nanoparticles (NPs). The superior wound healing activities achieved after nanoencapsulation of the CUR are attributed to its target-specific delivery, longer retention at the target site, avoiding premature degradation of the encapsulated cargo and the therapeutic superiority of the advanced delivery systems over the conventional delivery. We have critically reviewed the literature and summarize the convincing evidence which explore the pharmaceutical significance and therapeutic feasibility of the advanced delivery systems in improving wound healing activities of the CUR and its analogs.

Original languageEnglish
Pages (from-to)223-241
Number of pages19
JournalColloids and Surfaces B: Biointerfaces
Volume150
DOIs
Publication statusPublished - 1 Feb 2017

Fingerprint

wound healing
Curcumin
Wound Healing
Drug products
delivery
trends
healing
Nanoconjugates
Pharmaceutical Preparations
Hydrogels
Liposomes
Micelles
Nanofibers
Antioxidants
Metabolism
Scaffolds
Lipids
Restoration
analogs
Nanocomposites

Keywords

  • Advanced delivery systems
  • Curcumin
  • Efficacy upgradation
  • Improved tissue regeneration
  • Nanoencapsulation
  • Skin wound healing

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin : A review of new trends and state-of-the-art. / Hussain, Zahid; Thu, Hnin Ei; Ng, Shiow Fern; Khan, Shahzeb; Katas, Haliza.

In: Colloids and Surfaces B: Biointerfaces, Vol. 150, 01.02.2017, p. 223-241.

Research output: Contribution to journalReview article

@article{9d944e0b6f474a76b92f29590607a766,
title = "Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art",
abstract = "Wound healing is a multifarious and vibrant process of replacing devitalized and damaged cellular structures, leading to restoration of the skin's barrier function, re-establishment of tissue integrity, and maintenance of the internal homeostasis. Curcumin (CUR) and its analogs have gained widespread recognition due to their remarkable anti-inflammatory, anti-infective, anticancer, immunomodulatory, antioxidant, and wound healing activities. However, their pharmaceutical significance is limited due to inherent hydrophobic nature, poor water solubility, low bioavailability, chemical instability, rapid metabolism and short half-life. Owing to their pharmaceutical limitations, newer strategies have been attempted in recent years aiming to mitigate problems related to the effective delivery of curcumanoids and to improve their wound healing potential. These advanced strategies include nanovesicles, polymeric micelles, conventional liposomes and hyalurosomes, nanocomposite hydrogels, electrospun nanofibers, nanohybrid scaffolds, nanoconjugates, nanostructured lipid carriers (NLCs), nanoemulsion, nanodispersion, and polymeric nanoparticles (NPs). The superior wound healing activities achieved after nanoencapsulation of the CUR are attributed to its target-specific delivery, longer retention at the target site, avoiding premature degradation of the encapsulated cargo and the therapeutic superiority of the advanced delivery systems over the conventional delivery. We have critically reviewed the literature and summarize the convincing evidence which explore the pharmaceutical significance and therapeutic feasibility of the advanced delivery systems in improving wound healing activities of the CUR and its analogs.",
keywords = "Advanced delivery systems, Curcumin, Efficacy upgradation, Improved tissue regeneration, Nanoencapsulation, Skin wound healing",
author = "Zahid Hussain and Thu, {Hnin Ei} and Ng, {Shiow Fern} and Shahzeb Khan and Haliza Katas",
year = "2017",
month = "2",
day = "1",
doi = "10.1016/j.colsurfb.2016.11.036",
language = "English",
volume = "150",
pages = "223--241",
journal = "Colloids and Surfaces B: Biointerfaces",
issn = "0927-7765",
publisher = "Elsevier",

}

TY - JOUR

T1 - Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin

T2 - A review of new trends and state-of-the-art

AU - Hussain, Zahid

AU - Thu, Hnin Ei

AU - Ng, Shiow Fern

AU - Khan, Shahzeb

AU - Katas, Haliza

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Wound healing is a multifarious and vibrant process of replacing devitalized and damaged cellular structures, leading to restoration of the skin's barrier function, re-establishment of tissue integrity, and maintenance of the internal homeostasis. Curcumin (CUR) and its analogs have gained widespread recognition due to their remarkable anti-inflammatory, anti-infective, anticancer, immunomodulatory, antioxidant, and wound healing activities. However, their pharmaceutical significance is limited due to inherent hydrophobic nature, poor water solubility, low bioavailability, chemical instability, rapid metabolism and short half-life. Owing to their pharmaceutical limitations, newer strategies have been attempted in recent years aiming to mitigate problems related to the effective delivery of curcumanoids and to improve their wound healing potential. These advanced strategies include nanovesicles, polymeric micelles, conventional liposomes and hyalurosomes, nanocomposite hydrogels, electrospun nanofibers, nanohybrid scaffolds, nanoconjugates, nanostructured lipid carriers (NLCs), nanoemulsion, nanodispersion, and polymeric nanoparticles (NPs). The superior wound healing activities achieved after nanoencapsulation of the CUR are attributed to its target-specific delivery, longer retention at the target site, avoiding premature degradation of the encapsulated cargo and the therapeutic superiority of the advanced delivery systems over the conventional delivery. We have critically reviewed the literature and summarize the convincing evidence which explore the pharmaceutical significance and therapeutic feasibility of the advanced delivery systems in improving wound healing activities of the CUR and its analogs.

AB - Wound healing is a multifarious and vibrant process of replacing devitalized and damaged cellular structures, leading to restoration of the skin's barrier function, re-establishment of tissue integrity, and maintenance of the internal homeostasis. Curcumin (CUR) and its analogs have gained widespread recognition due to their remarkable anti-inflammatory, anti-infective, anticancer, immunomodulatory, antioxidant, and wound healing activities. However, their pharmaceutical significance is limited due to inherent hydrophobic nature, poor water solubility, low bioavailability, chemical instability, rapid metabolism and short half-life. Owing to their pharmaceutical limitations, newer strategies have been attempted in recent years aiming to mitigate problems related to the effective delivery of curcumanoids and to improve their wound healing potential. These advanced strategies include nanovesicles, polymeric micelles, conventional liposomes and hyalurosomes, nanocomposite hydrogels, electrospun nanofibers, nanohybrid scaffolds, nanoconjugates, nanostructured lipid carriers (NLCs), nanoemulsion, nanodispersion, and polymeric nanoparticles (NPs). The superior wound healing activities achieved after nanoencapsulation of the CUR are attributed to its target-specific delivery, longer retention at the target site, avoiding premature degradation of the encapsulated cargo and the therapeutic superiority of the advanced delivery systems over the conventional delivery. We have critically reviewed the literature and summarize the convincing evidence which explore the pharmaceutical significance and therapeutic feasibility of the advanced delivery systems in improving wound healing activities of the CUR and its analogs.

KW - Advanced delivery systems

KW - Curcumin

KW - Efficacy upgradation

KW - Improved tissue regeneration

KW - Nanoencapsulation

KW - Skin wound healing

UR - http://www.scopus.com/inward/record.url?scp=85000997466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85000997466&partnerID=8YFLogxK

U2 - 10.1016/j.colsurfb.2016.11.036

DO - 10.1016/j.colsurfb.2016.11.036

M3 - Review article

C2 - 27918967

AN - SCOPUS:85000997466

VL - 150

SP - 223

EP - 241

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

SN - 0927-7765

ER -