Nanoemulsi berasaskan olein sawit sebagai pembawa vitamin E

Translated title of the contribution: Nanoemulsion based palm olein as vitamin e carrier

Suria Ramli, Norhakimah Norhman, Norhidayu Zainuddin, Safiah Mohamad Ja’afar, Irman Abdul Rahman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aging process makes our skin getting thinner and drier. Antioxidant based on nanoemulsion system is favourable because of its effectiveness. This study was conducted to develop nanoemulsion system based on palm olein as a carrier of vitamin E and the physicochemical behaviours of the system were studied. Palm olein as oil phase, polyoxyethylene (4) lauryl ether (Brij 30) was used as a surfactant and vitamin E as an anti-aging agent. The mixtures of Brij 30 and palm olein at certain ratios were thoroughly mixed and titrated with 5-95% wt. of water and homogenized by using homogenizer. The Palm olein/Brij 30/Water mixtures that produced a clear solution and no birefringence after observation under polarized light microscopy are labelled as nanoemulsion. Nanoemulsion region was shown in ternary phase diagram. Based on the ternary diagram, these systems were formed at oil: surfactant (O/S) ratio 4:6, 5:5 and 6:4 and 20-50% wt of water. These systems were then characterized for stability test, particle size, electrical conductivity, viscosity and pH. Stability test was done at three temperatures, which were 4, 25 and 40 °C for one month and four cycles of freeze-thaw at storage temperature for 12 hours at each temperature. The systems were stable and no phase separation was observed. Particle size analysis showed that most systems have a particle size within the range of nanoemulsion (20-500 nm). Electrical conductivity tests showed that water-in-oil system formed at low water percentage (20-30% wt. of water) and bicontinuous at a higher percentage (30-50% wt. of water). Viscosity of both systems vitamin E-loaded and unloaded is very low. All systems have a pH value in a range of 6-7, which are suitable to be applied to human skin. Based on the physical characteristics of the system, it shows high potential as a vitamin E carrier.

Original languageMalay
Pages (from-to)1399-1408
Number of pages10
JournalMalaysian Journal of Analytical Sciences
Volume21
Issue number6
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

Vitamins
Water
Vitamin E
Oils
Surface-Active Agents
Skin
Aging of materials
Particle size
Viscosity
Light polarization
Birefringence
Particle size analysis
Phase separation
Temperature
Phase diagrams
Optical microscopy
Antioxidants
Brij 30

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Nanoemulsi berasaskan olein sawit sebagai pembawa vitamin E. / Ramli, Suria; Norhman, Norhakimah; Zainuddin, Norhidayu; Ja’afar, Safiah Mohamad; Abdul Rahman, Irman.

In: Malaysian Journal of Analytical Sciences, Vol. 21, No. 6, 01.12.2017, p. 1399-1408.

Research output: Contribution to journalArticle

Ramli, Suria ; Norhman, Norhakimah ; Zainuddin, Norhidayu ; Ja’afar, Safiah Mohamad ; Abdul Rahman, Irman. / Nanoemulsi berasaskan olein sawit sebagai pembawa vitamin E. In: Malaysian Journal of Analytical Sciences. 2017 ; Vol. 21, No. 6. pp. 1399-1408.
@article{2b660a824d0147a2a71baf6d78975606,
title = "Nanoemulsi berasaskan olein sawit sebagai pembawa vitamin E",
abstract = "Aging process makes our skin getting thinner and drier. Antioxidant based on nanoemulsion system is favourable because of its effectiveness. This study was conducted to develop nanoemulsion system based on palm olein as a carrier of vitamin E and the physicochemical behaviours of the system were studied. Palm olein as oil phase, polyoxyethylene (4) lauryl ether (Brij 30) was used as a surfactant and vitamin E as an anti-aging agent. The mixtures of Brij 30 and palm olein at certain ratios were thoroughly mixed and titrated with 5-95{\%} wt. of water and homogenized by using homogenizer. The Palm olein/Brij 30/Water mixtures that produced a clear solution and no birefringence after observation under polarized light microscopy are labelled as nanoemulsion. Nanoemulsion region was shown in ternary phase diagram. Based on the ternary diagram, these systems were formed at oil: surfactant (O/S) ratio 4:6, 5:5 and 6:4 and 20-50{\%} wt of water. These systems were then characterized for stability test, particle size, electrical conductivity, viscosity and pH. Stability test was done at three temperatures, which were 4, 25 and 40 °C for one month and four cycles of freeze-thaw at storage temperature for 12 hours at each temperature. The systems were stable and no phase separation was observed. Particle size analysis showed that most systems have a particle size within the range of nanoemulsion (20-500 nm). Electrical conductivity tests showed that water-in-oil system formed at low water percentage (20-30{\%} wt. of water) and bicontinuous at a higher percentage (30-50{\%} wt. of water). Viscosity of both systems vitamin E-loaded and unloaded is very low. All systems have a pH value in a range of 6-7, which are suitable to be applied to human skin. Based on the physical characteristics of the system, it shows high potential as a vitamin E carrier.",
keywords = "Anti-aging agent, Nanoemulsion, Palm olein, Ternary phase diagram, Vitamin E",
author = "Suria Ramli and Norhakimah Norhman and Norhidayu Zainuddin and Ja’afar, {Safiah Mohamad} and {Abdul Rahman}, Irman",
year = "2017",
month = "12",
day = "1",
doi = "10.17576/mjas-2017-2106-22",
language = "Malay",
volume = "21",
pages = "1399--1408",
journal = "Malaysian Journal of Analytical Sciences",
issn = "1394-2506",
publisher = "Faculty of Science and Technology, Universiti Kebangsaan Malaysia",
number = "6",

}

TY - JOUR

T1 - Nanoemulsi berasaskan olein sawit sebagai pembawa vitamin E

AU - Ramli, Suria

AU - Norhman, Norhakimah

AU - Zainuddin, Norhidayu

AU - Ja’afar, Safiah Mohamad

AU - Abdul Rahman, Irman

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Aging process makes our skin getting thinner and drier. Antioxidant based on nanoemulsion system is favourable because of its effectiveness. This study was conducted to develop nanoemulsion system based on palm olein as a carrier of vitamin E and the physicochemical behaviours of the system were studied. Palm olein as oil phase, polyoxyethylene (4) lauryl ether (Brij 30) was used as a surfactant and vitamin E as an anti-aging agent. The mixtures of Brij 30 and palm olein at certain ratios were thoroughly mixed and titrated with 5-95% wt. of water and homogenized by using homogenizer. The Palm olein/Brij 30/Water mixtures that produced a clear solution and no birefringence after observation under polarized light microscopy are labelled as nanoemulsion. Nanoemulsion region was shown in ternary phase diagram. Based on the ternary diagram, these systems were formed at oil: surfactant (O/S) ratio 4:6, 5:5 and 6:4 and 20-50% wt of water. These systems were then characterized for stability test, particle size, electrical conductivity, viscosity and pH. Stability test was done at three temperatures, which were 4, 25 and 40 °C for one month and four cycles of freeze-thaw at storage temperature for 12 hours at each temperature. The systems were stable and no phase separation was observed. Particle size analysis showed that most systems have a particle size within the range of nanoemulsion (20-500 nm). Electrical conductivity tests showed that water-in-oil system formed at low water percentage (20-30% wt. of water) and bicontinuous at a higher percentage (30-50% wt. of water). Viscosity of both systems vitamin E-loaded and unloaded is very low. All systems have a pH value in a range of 6-7, which are suitable to be applied to human skin. Based on the physical characteristics of the system, it shows high potential as a vitamin E carrier.

AB - Aging process makes our skin getting thinner and drier. Antioxidant based on nanoemulsion system is favourable because of its effectiveness. This study was conducted to develop nanoemulsion system based on palm olein as a carrier of vitamin E and the physicochemical behaviours of the system were studied. Palm olein as oil phase, polyoxyethylene (4) lauryl ether (Brij 30) was used as a surfactant and vitamin E as an anti-aging agent. The mixtures of Brij 30 and palm olein at certain ratios were thoroughly mixed and titrated with 5-95% wt. of water and homogenized by using homogenizer. The Palm olein/Brij 30/Water mixtures that produced a clear solution and no birefringence after observation under polarized light microscopy are labelled as nanoemulsion. Nanoemulsion region was shown in ternary phase diagram. Based on the ternary diagram, these systems were formed at oil: surfactant (O/S) ratio 4:6, 5:5 and 6:4 and 20-50% wt of water. These systems were then characterized for stability test, particle size, electrical conductivity, viscosity and pH. Stability test was done at three temperatures, which were 4, 25 and 40 °C for one month and four cycles of freeze-thaw at storage temperature for 12 hours at each temperature. The systems were stable and no phase separation was observed. Particle size analysis showed that most systems have a particle size within the range of nanoemulsion (20-500 nm). Electrical conductivity tests showed that water-in-oil system formed at low water percentage (20-30% wt. of water) and bicontinuous at a higher percentage (30-50% wt. of water). Viscosity of both systems vitamin E-loaded and unloaded is very low. All systems have a pH value in a range of 6-7, which are suitable to be applied to human skin. Based on the physical characteristics of the system, it shows high potential as a vitamin E carrier.

KW - Anti-aging agent

KW - Nanoemulsion

KW - Palm olein

KW - Ternary phase diagram

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=85039698618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039698618&partnerID=8YFLogxK

U2 - 10.17576/mjas-2017-2106-22

DO - 10.17576/mjas-2017-2106-22

M3 - Article

AN - SCOPUS:85039698618

VL - 21

SP - 1399

EP - 1408

JO - Malaysian Journal of Analytical Sciences

JF - Malaysian Journal of Analytical Sciences

SN - 1394-2506

IS - 6

ER -