Multiple oesophago-respiratory fistulae

Sequelae of pulmonary tuberculosis in retroviral infection

Research output: Contribution to journalArticle

Abstract

Pulmonary tuberculosis (PTB) is a common infectious disease worldwide. However, mediastinal tuberculous lymphadenitis complicated by oesophageal involvement and oesophago-respiratory fistula is now uncommon due to improved anti-tuberculous regimes and better general awareness. The overall incidence of acquired oesophago-respiratory fistula due to infection is low, and therefore, the lesion is not often a frontrunner in differential diagnosis. Still, tuberculous oesophago-respiratory fistulae can potentially occur in patients with retroviral disease, as they tend to have atypical and more virulent manifestations. In this study, we report the case of multiple oesophago-respiratory fistulae in a patient with PTB and retroviral disease, and highlight the computed tomography features of these lesions as an atypical presentation of PTB in retroviral disease. Clinicians should suspect oesophago-respiratory fistulae if patients present with Ono's sign, and remain particularly vigilant for patients with underlying PTB and retroviral disease, as early diagnosis and treatment could help to reduce mortality.

Original languageEnglish
JournalSingapore Medical Journal
Volume55
Issue number7
DOIs
Publication statusPublished - 2014

Fingerprint

Pulmonary Tuberculosis
Fistula
Infection
Lymph Node Tuberculosis
Communicable Diseases
Early Diagnosis
Differential Diagnosis
Tomography
Mortality
Incidence
Therapeutics

Keywords

  • Oesophago-bronchial fistula
  • Oesophago-mediastinal fistula
  • Oesophago-pulmonary fistula
  • Oesophago-respiratory fistula
  • Pulmonary tuberculosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Multiple oesophago-respiratory fistulae: Sequelae of pulmonary tuberculosis in retroviral infection",
abstract = "Pulmonary tuberculosis (PTB) is a common infectious disease worldwide. However, mediastinal tuberculous lymphadenitis complicated by oesophageal involvement and oesophago-respiratory fistula is now uncommon due to improved anti-tuberculous regimes and better general awareness. The overall incidence of acquired oesophago-respiratory fistula due to infection is low, and therefore, the lesion is not often a frontrunner in differential diagnosis. Still, tuberculous oesophago-respiratory fistulae can potentially occur in patients with retroviral disease, as they tend to have atypical and more virulent manifestations. In this study, we report the case of multiple oesophago-respiratory fistulae in a patient with PTB and retroviral disease, and highlight the computed tomography features of these lesions as an atypical presentation of PTB in retroviral disease. Clinicians should suspect oesophago-respiratory fistulae if patients present with Ono's sign, and remain particularly vigilant for patients with underlying PTB and retroviral disease, as early diagnosis and treatment could help to reduce mortality.",
keywords = "Oesophago-bronchial fistula, Oesophago-mediastinal fistula, Oesophago-pulmonary fistula, Oesophago-respiratory fistula, Pulmonary tuberculosis",
author = "Low, {Soo Fin} and {Chai Soon}, Ngiu and {Erica Yee Hing}, Wong and {Abu Bakar}, Norzailin",
year = "2014",
doi = "10.11622/smedj.2013259",
language = "English",
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journal = "Singapore Medical Journal",
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T2 - Sequelae of pulmonary tuberculosis in retroviral infection

AU - Low, Soo Fin

AU - Chai Soon, Ngiu

AU - Erica Yee Hing, Wong

AU - Abu Bakar, Norzailin

PY - 2014

Y1 - 2014

N2 - Pulmonary tuberculosis (PTB) is a common infectious disease worldwide. However, mediastinal tuberculous lymphadenitis complicated by oesophageal involvement and oesophago-respiratory fistula is now uncommon due to improved anti-tuberculous regimes and better general awareness. The overall incidence of acquired oesophago-respiratory fistula due to infection is low, and therefore, the lesion is not often a frontrunner in differential diagnosis. Still, tuberculous oesophago-respiratory fistulae can potentially occur in patients with retroviral disease, as they tend to have atypical and more virulent manifestations. In this study, we report the case of multiple oesophago-respiratory fistulae in a patient with PTB and retroviral disease, and highlight the computed tomography features of these lesions as an atypical presentation of PTB in retroviral disease. Clinicians should suspect oesophago-respiratory fistulae if patients present with Ono's sign, and remain particularly vigilant for patients with underlying PTB and retroviral disease, as early diagnosis and treatment could help to reduce mortality.

AB - Pulmonary tuberculosis (PTB) is a common infectious disease worldwide. However, mediastinal tuberculous lymphadenitis complicated by oesophageal involvement and oesophago-respiratory fistula is now uncommon due to improved anti-tuberculous regimes and better general awareness. The overall incidence of acquired oesophago-respiratory fistula due to infection is low, and therefore, the lesion is not often a frontrunner in differential diagnosis. Still, tuberculous oesophago-respiratory fistulae can potentially occur in patients with retroviral disease, as they tend to have atypical and more virulent manifestations. In this study, we report the case of multiple oesophago-respiratory fistulae in a patient with PTB and retroviral disease, and highlight the computed tomography features of these lesions as an atypical presentation of PTB in retroviral disease. Clinicians should suspect oesophago-respiratory fistulae if patients present with Ono's sign, and remain particularly vigilant for patients with underlying PTB and retroviral disease, as early diagnosis and treatment could help to reduce mortality.

KW - Oesophago-bronchial fistula

KW - Oesophago-mediastinal fistula

KW - Oesophago-pulmonary fistula

KW - Oesophago-respiratory fistula

KW - Pulmonary tuberculosis

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