Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma.

M. S. Shiran, Geok Chin Tan, M. S. Kenali, A. R. Sabariah, R. Pathmanathan

Research output: Contribution to journalArticle

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Abstract

Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy (SHML), is a systemic disease involving nodal and extranodal tissues. We report a 48-year-old female with recurrent nasal obstruction due to polypoidal masses involving the nasal sinuses, turbinates and septum bilaterally, and lumps in the right infra-orbital region and region of the right lacrimal sac. A 4 cm right upper neck mass was also noted, which was initially diagnosed as histiocytic lymphoma. Histopathology of the nasal and infraorbital lesions revealed fibro-inflammatory masses containing histiocytic cells with large vesicular nuclei and abundant foamy cytoplasm exhibiting emperipolesis and lymphophagocytosis, admixed with scattered plasma cells and lymphocytes. These histiocytes revealed immunohistochemical positivity for S-100 protein and CD68, but were negative for CDla. The findings supported a diagnosis of RDD. This report serves to remind pathologists and clinicians of the extranodal manifestations of RDD and its potential confusion with lymphomas.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalThe Malaysian journal of pathology
Volume30
Issue number1
Publication statusPublished - Jun 2008
Externally publishedYes

Fingerprint

Sinus Histiocytosis
Lymphoma, Large B-Cell, Diffuse
Emperipolesis
Nasolacrimal Duct
Nasal Septum
Turbinates
Nasal Obstruction
Histiocytes
S100 Proteins
Paranasal Sinuses
Plasma Cells
Nose
Lymphoma
Cytoplasm
Neck
Lymphocytes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma. / Shiran, M. S.; Tan, Geok Chin; Kenali, M. S.; Sabariah, A. R.; Pathmanathan, R.

In: The Malaysian journal of pathology, Vol. 30, No. 1, 06.2008, p. 63-65.

Research output: Contribution to journalArticle

Shiran, M. S. ; Tan, Geok Chin ; Kenali, M. S. ; Sabariah, A. R. ; Pathmanathan, R. / Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma. In: The Malaysian journal of pathology. 2008 ; Vol. 30, No. 1. pp. 63-65.
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