Multi-targetable chalcone analogs to treat deadly Alzheimer's disease: Current view and upcoming advice

Xu Zhang, K. P. Rakesh, Bukhari Syed Nasir Abbas, Moku Balakrishna, H. M. Manukumar, Hua Li Qin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The complications of Alzheimer's disease AD were deadly dangerous cause of neurodegenerative disorders connected with the decline of the cognitive functions and loss of memory. The common form of dementia is accounted as the sixth leading cause of the death affecting any stage of people in a lifetime. Synthetic natural chalcone analogs were currently a hot research topic for the treatment of (AD) which has affected millions of peoples throughout the world. The present aim was set to understand the important problems of the AD and its treatment based on natural derivatives of novel chalcones. One interesting strategy currently of searching for the treatment of AD is to find inhibitors for acetylcholinesterase (AChE) and using metal chelators to target amyloid-β (Aβ) peptides, and then metal-Aβ complexes for the AD pathogenesis. The present compressed review focuses and highlights the design and synthesis of new approaches for the construction of important chalcones playing multiple beneficiary roles in the AD treatments. These hallmarks of concurred research represent the immediate needs of development of novel therapeutic drugs for effective treatment of ADs by understanding the specific pharmacology targets.

Original languageEnglish
Pages (from-to)86-93
Number of pages8
JournalBioorganic Chemistry
Volume80
DOIs
Publication statusPublished - 1 Oct 2018
Externally publishedYes

Fingerprint

Chalcones
Chalcone
Alzheimer Disease
Metals
Cholinesterase Inhibitors
Coordination Complexes
Memory Disorders
Chelating Agents
Research
Amyloid
Neurodegenerative Diseases
Cognition
Dementia
Cause of Death
Pharmacology
Derivatives
Data storage equipment
Peptides
Pharmaceutical Preparations
Therapeutics

Keywords

  • Alzheimer's disease
  • Chalcone
  • Docking
  • SAR

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

Cite this

Zhang, X., Rakesh, K. P., Syed Nasir Abbas, B., Balakrishna, M., Manukumar, H. M., & Qin, H. L. (2018). Multi-targetable chalcone analogs to treat deadly Alzheimer's disease: Current view and upcoming advice. Bioorganic Chemistry, 80, 86-93. https://doi.org/10.1016/j.bioorg.2018.06.009

Multi-targetable chalcone analogs to treat deadly Alzheimer's disease : Current view and upcoming advice. / Zhang, Xu; Rakesh, K. P.; Syed Nasir Abbas, Bukhari; Balakrishna, Moku; Manukumar, H. M.; Qin, Hua Li.

In: Bioorganic Chemistry, Vol. 80, 01.10.2018, p. 86-93.

Research output: Contribution to journalArticle

Zhang, X, Rakesh, KP, Syed Nasir Abbas, B, Balakrishna, M, Manukumar, HM & Qin, HL 2018, 'Multi-targetable chalcone analogs to treat deadly Alzheimer's disease: Current view and upcoming advice', Bioorganic Chemistry, vol. 80, pp. 86-93. https://doi.org/10.1016/j.bioorg.2018.06.009
Zhang, Xu ; Rakesh, K. P. ; Syed Nasir Abbas, Bukhari ; Balakrishna, Moku ; Manukumar, H. M. ; Qin, Hua Li. / Multi-targetable chalcone analogs to treat deadly Alzheimer's disease : Current view and upcoming advice. In: Bioorganic Chemistry. 2018 ; Vol. 80. pp. 86-93.
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