Multi-disciplinary approach for managing plasmacytoma

A case report

Wint Wint Thu Nyunt, Rahayu Draman, Aida Widure Mohd Mustapha, Noralisa Abdul Karim, Mohd Razif Mohd Idris, Noraimy Abdullah, Yee Loong Tang, Wan Fariza Wan Jamaludin, Noraidah Masir, S. Fadilah S.Abdul Wahid

Research output: Contribution to journalArticle

Abstract

Solitary plasmacytoma (SP) is a tumor with evidence of clonal plasma cells and no other features of multiple myeloma (MM). We report a case of SP which showed multiple recurrences of SP and then evolution into overt MM. A 56-year-old man presented with the 5-month-history of right nasal obstruction and intermittent epistaxis. He had SP (extraosseous) of right nasopharynx (3.5 × 2 × 2.5 cm), with no paraproteinaemia. He received radiotherapy (56 Gy), achieving complete remission. Ten years later, he had recurrence of SP (osseous) in left tibia, presenting with pathological fracture. He received radiotherapy (50 Gy), achieving partial response. Three years later, he had recurrence of SP (osseous) in right tibia, presenting with right leg pain. He received radiotherapy (45 Gy). While receiving treatment, he had progressive swelling in the area around right eye, double vision and headache. Imaging scans showed multiple plasmacytomas. There were presence of monoclonal paraprotein, hypercalcemia and lytic bone lesions. He was diagnosed as MM (at the age of 70 years) and treated with Bortezomib-based therapy. Currently, after one cycle of treatment, clinical improvement is achieved. The importance of multi-disciplinary team approach for managing patients with plasmacytoma is highlighted in order to achieve the holistic approach of management.

Original languageEnglish
Pages (from-to)2113-2118
Number of pages6
JournalSains Malaysiana
Volume47
Issue number9
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Plasmacytoma
Multiple Myeloma
Radiotherapy
Tibia
Recurrence
Paraproteins
Spontaneous Fractures
Nasal Obstruction
Paraproteinemias
Epistaxis
Diplopia
Nasopharynx
Hypercalcemia
Plasma Cells
Headache
Leg
Therapeutics
Bone and Bones
Pain

Keywords

  • Multiple myeloma
  • Plasma cell proliferative disorder
  • Plasmacytoma

ASJC Scopus subject areas

  • General

Cite this

Nyunt, W. W. T., Draman, R., Mustapha, A. W. M., Karim, N. A., Idris, M. R. M., Abdullah, N., ... Wahid, S. F. S. A. (2018). Multi-disciplinary approach for managing plasmacytoma: A case report. Sains Malaysiana, 47(9), 2113-2118. https://doi.org/10.17576/jsm-2018-4709-20

Multi-disciplinary approach for managing plasmacytoma : A case report. / Nyunt, Wint Wint Thu; Draman, Rahayu; Mustapha, Aida Widure Mohd; Karim, Noralisa Abdul; Idris, Mohd Razif Mohd; Abdullah, Noraimy; Tang, Yee Loong; Jamaludin, Wan Fariza Wan; Masir, Noraidah; Wahid, S. Fadilah S.Abdul.

In: Sains Malaysiana, Vol. 47, No. 9, 01.01.2018, p. 2113-2118.

Research output: Contribution to journalArticle

Nyunt, WWT, Draman, R, Mustapha, AWM, Karim, NA, Idris, MRM, Abdullah, N, Tang, YL, Jamaludin, WFW, Masir, N & Wahid, SFSA 2018, 'Multi-disciplinary approach for managing plasmacytoma: A case report', Sains Malaysiana, vol. 47, no. 9, pp. 2113-2118. https://doi.org/10.17576/jsm-2018-4709-20
Nyunt WWT, Draman R, Mustapha AWM, Karim NA, Idris MRM, Abdullah N et al. Multi-disciplinary approach for managing plasmacytoma: A case report. Sains Malaysiana. 2018 Jan 1;47(9):2113-2118. https://doi.org/10.17576/jsm-2018-4709-20
Nyunt, Wint Wint Thu ; Draman, Rahayu ; Mustapha, Aida Widure Mohd ; Karim, Noralisa Abdul ; Idris, Mohd Razif Mohd ; Abdullah, Noraimy ; Tang, Yee Loong ; Jamaludin, Wan Fariza Wan ; Masir, Noraidah ; Wahid, S. Fadilah S.Abdul. / Multi-disciplinary approach for managing plasmacytoma : A case report. In: Sains Malaysiana. 2018 ; Vol. 47, No. 9. pp. 2113-2118.
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