MTHFR C677T polymorphism as a risk factor of neural tube defects in Malay

A case control study

A. R. Hayati, A. I. Zainal, Geok Chin Tan, L. C. Ong, T. B. Khoo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Major congenital malformations occur in about 3% of newborn. Several studies have suggested that homozygosity for the C677T methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs). It has been hypothesized that the maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme. This association has not been found in some ethnic groups. In this study, we attempted to assess the association between NTDs and MTHFR C677T in Malaysian Malay population. Results show that MTHFR 677TT genotype was absent in both patient and control qroups.

Original languageEnglish
Pages (from-to)379-383
Number of pages5
JournalMedical Journal of Malaysia
Volume63
Issue number5
Publication statusPublished - Dec 2008

Fingerprint

Methylenetetrahydrofolate Reductase (NADPH2)
Neural Tube Defects
Case-Control Studies
Folic Acid
Ethnic Groups
Genotype
Mothers
Newborn Infant
Enzymes
Population

Keywords

  • Genetics
  • Malay ethnic
  • MTHFR C677T
  • Neural tube defects
  • Polymorphism

ASJC Scopus subject areas

  • Medicine(all)

Cite this

MTHFR C677T polymorphism as a risk factor of neural tube defects in Malay : A case control study. / Hayati, A. R.; Zainal, A. I.; Tan, Geok Chin; Ong, L. C.; Khoo, T. B.

In: Medical Journal of Malaysia, Vol. 63, No. 5, 12.2008, p. 379-383.

Research output: Contribution to journalArticle

Hayati, A. R. ; Zainal, A. I. ; Tan, Geok Chin ; Ong, L. C. ; Khoo, T. B. / MTHFR C677T polymorphism as a risk factor of neural tube defects in Malay : A case control study. In: Medical Journal of Malaysia. 2008 ; Vol. 63, No. 5. pp. 379-383.
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