Abstract
Major congenital malformations occur in about 3% of newborn. Several studies have suggested that homozygosity for the C677T methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs). It has been hypothesized that the maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme. This association has not been found in some ethnic groups. In this study, we attempted to assess the association between NTDs and MTHFR C677T in Malaysian Malay population. Results show that MTHFR 677TT genotype was absent in both patient and control qroups.
| Original language | English |
|---|---|
| Pages (from-to) | 379-383 |
| Number of pages | 5 |
| Journal | Medical Journal of Malaysia |
| Volume | 63 |
| Issue number | 5 |
| Publication status | Published - Dec 2008 |
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Keywords
- Genetics
- Malay ethnic
- MTHFR C677T
- Neural tube defects
- Polymorphism
ASJC Scopus subject areas
- Medicine(all)
Cite this
MTHFR C677T polymorphism as a risk factor of neural tube defects in Malay : A case control study. / Hayati, A. R.; Zainal, A. I.; Tan, Geok Chin; Ong, L. C.; Khoo, T. B.
In: Medical Journal of Malaysia, Vol. 63, No. 5, 12.2008, p. 379-383.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MTHFR C677T polymorphism as a risk factor of neural tube defects in Malay
T2 - A case control study
AU - Hayati, A. R.
AU - Zainal, A. I.
AU - Tan, Geok Chin
AU - Ong, L. C.
AU - Khoo, T. B.
PY - 2008/12
Y1 - 2008/12
N2 - Major congenital malformations occur in about 3% of newborn. Several studies have suggested that homozygosity for the C677T methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs). It has been hypothesized that the maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme. This association has not been found in some ethnic groups. In this study, we attempted to assess the association between NTDs and MTHFR C677T in Malaysian Malay population. Results show that MTHFR 677TT genotype was absent in both patient and control qroups.
AB - Major congenital malformations occur in about 3% of newborn. Several studies have suggested that homozygosity for the C677T methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs). It has been hypothesized that the maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme. This association has not been found in some ethnic groups. In this study, we attempted to assess the association between NTDs and MTHFR C677T in Malaysian Malay population. Results show that MTHFR 677TT genotype was absent in both patient and control qroups.
KW - Genetics
KW - Malay ethnic
KW - MTHFR C677T
KW - Neural tube defects
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=60849088608&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=60849088608&partnerID=8YFLogxK
M3 - Article
C2 - 19803295
AN - SCOPUS:60849088608
VL - 63
SP - 379
EP - 383
JO - Medical Journal of Malaysia
JF - Medical Journal of Malaysia
SN - 0300-5283
IS - 5
ER -