Motor dexterity and strength depend upon integrity of the attention-control system

Paul Rinne, Mursyida Hassan, Cristina Fernandes, Erika Han, Emma Hennessy, Adam Waldman, Pankaj Sharma, David Soto, Robert Leech, Paresh A. Malhotra, Paul Bentley

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Attention control (or executive control) is a higher cognitive function involved in response selection and inhibition, through close interactions with the motor system. Here, we tested whether influences of attention control are also seen on lower level motor functions of dexterity and strength—by examining relationships between attention control and motor performance in healthy-aged and hemiparetic-stroke subjects (n = 93 and 167, respectively). Subjects undertook simple-tracking, precision-hold, and maximum force-generation tasks, with each hand. Performance across all tasks correlated strongly with attention control (measured as distractor resistance), independently of factors such as baseline performance, hand use, lesion size, mood, fatigue, or whether distraction was tested during motor or nonmotor cognitive tasks. Critically, asymmetric dissociations occurred in all tasks, in that severe motor impairment coexisted with normal (or impaired) attention control whereas normal motor performance was never associated with impaired attention control (below a task-dependent threshold). This implies that dexterity and force generation require intact attention control. Subsequently, we examined how motor and attention-control performance mapped to lesion location and cerebral functional connectivity. One component of motor performance (common to both arms), as well as attention control, correlated with the anatomical and functional integrity of a cingulo-opercular “salience” network. Independently of this, motor performance difference between arms correlated negatively with the integrity of the primary sensorimotor network and corticospinal tract. These results suggest that the salience network, and its attention-control function, are necessary for virtually all volitional motor acts while its damage contributes significantly to the cardinal motor deficits of stroke.

Original languageEnglish
Pages (from-to)E536-E545
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number3
DOIs
Publication statusPublished - 16 Jan 2018

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Arm
Hand
Stroke
Dissociative Disorders
Pyramidal Tracts
R Factors
Executive Function
Advisory Committees
Cognition
Fatigue
Inhibition (Psychology)

Keywords

  • Attention
  • Cognitive control
  • FMRI
  • Motor
  • Stroke

ASJC Scopus subject areas

  • General

Cite this

Motor dexterity and strength depend upon integrity of the attention-control system. / Rinne, Paul; Hassan, Mursyida; Fernandes, Cristina; Han, Erika; Hennessy, Emma; Waldman, Adam; Sharma, Pankaj; Soto, David; Leech, Robert; Malhotra, Paresh A.; Bentley, Paul.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 3, 16.01.2018, p. E536-E545.

Research output: Contribution to journalArticle

Rinne, P, Hassan, M, Fernandes, C, Han, E, Hennessy, E, Waldman, A, Sharma, P, Soto, D, Leech, R, Malhotra, PA & Bentley, P 2018, 'Motor dexterity and strength depend upon integrity of the attention-control system', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 3, pp. E536-E545. https://doi.org/10.1073/pnas.1715617115
Rinne, Paul ; Hassan, Mursyida ; Fernandes, Cristina ; Han, Erika ; Hennessy, Emma ; Waldman, Adam ; Sharma, Pankaj ; Soto, David ; Leech, Robert ; Malhotra, Paresh A. ; Bentley, Paul. / Motor dexterity and strength depend upon integrity of the attention-control system. In: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; Vol. 115, No. 3. pp. E536-E545.
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