Mortality in Malaysians with systemic lupus erythematosus

N. I J Paton, I. Cheong, N. C T Kong, M. Segasothy

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

One hundred and two patients attending the systemic lupus erythematosus (SLE) clinic of the Department of Medicine, Universiti Kebangsaan Malaysia, were studied retrospectively to determined their survival-rates and causes of death. There were 21 deaths. The 1, 5, and 10 year survival rates were 93%, 86% and 70% respectively. There was a bimodal pattern of mortality with more patients dying the first 2 years or after 5 years of disease. Infection was the direct cause of death in 52% and contributed to a further 19% of deaths. Patients with lupus nephritis had a higher relative risk (RR) of death (RR=4.34, p<0.02) although there was no significant increase in risk with any particular histological type on biopsy. Cerebral lupus (RR=3.08, p<0.001) and methylprednisolone treatment (RR=6.24, p<0.001) were also associated with increased risk of death. Increased awareness of infection and earlier use of antibiotic therapy may improve survival of patients suffering from SLE.

Original languageEnglish
Pages (from-to)437-441
Number of pages5
JournalMedical Journal of Malaysia
Volume51
Issue number4
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Systemic Lupus Erythematosus
Mortality
Cause of Death
Survival Rate
Lupus Nephritis
Malaysia
Methylprednisolone
Infection
Medicine
Anti-Bacterial Agents
Biopsy
Survival
Therapeutics

Keywords

  • Infection
  • Lupus nephritis
  • Methylprednisolone
  • Mortality in systemic lupus erythematosus
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Paton, N. I. J., Cheong, I., Kong, N. C. T., & Segasothy, M. (1996). Mortality in Malaysians with systemic lupus erythematosus. Medical Journal of Malaysia, 51(4), 437-441.

Mortality in Malaysians with systemic lupus erythematosus. / Paton, N. I J; Cheong, I.; Kong, N. C T; Segasothy, M.

In: Medical Journal of Malaysia, Vol. 51, No. 4, 1996, p. 437-441.

Research output: Contribution to journalArticle

Paton, NIJ, Cheong, I, Kong, NCT & Segasothy, M 1996, 'Mortality in Malaysians with systemic lupus erythematosus', Medical Journal of Malaysia, vol. 51, no. 4, pp. 437-441.
Paton NIJ, Cheong I, Kong NCT, Segasothy M. Mortality in Malaysians with systemic lupus erythematosus. Medical Journal of Malaysia. 1996;51(4):437-441.
Paton, N. I J ; Cheong, I. ; Kong, N. C T ; Segasothy, M. / Mortality in Malaysians with systemic lupus erythematosus. In: Medical Journal of Malaysia. 1996 ; Vol. 51, No. 4. pp. 437-441.
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