Monosodium glutamate daily oral supplementation

study of its effects on male reproductive system on rat model

Fatin Farhana Jubaidi, Ramya Dewi Mathialagan, Mahanem Mat Noor, Taib Izatus Shima, Siti Balkis Budin

Research output: Contribution to journalArticle

Abstract

Monosodium glutamate (MSG) is widely used in food preparation industry and has been consumed regularly. Previous studies had reported on effects of MSG when given at extremely high dosages, the results are not applicable to human equivalent intake. Therefore, the present study aimed to evaluate the effect of MSG on sperm quality and changes in reproductive organs of adult male rats when taken at average human daily intake (ADI). Twenty-four adult male rats were randomly assigned into three groups; NC (Normal control), MSG60 and MSG120 where MSG was given orally at 60 mg/kg and 120 mg/kg to each respective group. All treatments were conducted for 28 consecutive days. MSG at estimated ADI of 120 mg/kg body weight resulted in a significant drop in sperm quality (p < 0.05) when compared to both control and MSG60 groups. A significant decrease in the weight of reproductive organs was also apparent (p < 0.05). Moreover, oxidative status evaluation showed that treatment of MSG induces oxidative stress in the testis, more severely at a dose of 120 mg/kg body weight. These findings are supported by alterations in the observed histology of reproductive organs. This study shows that an intake dose of 120 mg/kg body weight MSG could cause significant damage to the reproductive system. Abbreviations: MSG: Monosodium glutamate; ADI: average daily intake; PUFA: polyunsaturated fatty acid; FSH: follicle stimulating hormone; LH: luteinizing hormone; TCA: tricarbocylic acid; PF: prostatic fluid.

Original languageEnglish
Pages (from-to)194-204
Number of pages11
JournalSystems biology in reproductive medicine
Volume65
Issue number3
DOIs
Publication statusPublished - 1 Jun 2019

Fingerprint

Sodium Glutamate
Body Weight
Spermatozoa
Organ Size
Food Industry
Follicle Stimulating Hormone
Luteinizing Hormone
Unsaturated Fatty Acids
Testis
Histology
Oxidative Stress
Control Groups
Acids

Keywords

  • accessory organs
  • Food enhancer
  • monosodium glutamate
  • sperm quality
  • testis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

Cite this

Monosodium glutamate daily oral supplementation : study of its effects on male reproductive system on rat model. / Jubaidi, Fatin Farhana; Mathialagan, Ramya Dewi; Mat Noor, Mahanem; Izatus Shima, Taib; Budin, Siti Balkis.

In: Systems biology in reproductive medicine, Vol. 65, No. 3, 01.06.2019, p. 194-204.

Research output: Contribution to journalArticle

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