Monoclonal gammopathy with systemic amyloidosis: An evaluation of diagnostic elements

C. T. Subashini, E. George, U. Nor Aini

    Research output: Contribution to journalArticle

    Abstract

    Monoclonal gammopathies result from an overproduction of a single abnormal clone of plasma cell or B lymphocyte that produce an immunologically homogenous immunoglobulin (Ig) commonly referred to as paraprotein or monoclonal (M) protein. The circulating M-protein may consist of an intact immunoglobulin, the light chain only, or (rarely) the heavy chain only. The heavy chain is from one of the five immunoglobulin classes G, A, M, D or E, while the light chain is either kappa (κ) or lambda (λ) in type. Accurate detection and quantitation of monoclonal immunoglobulins is important for the diagnosis and management of monoclonal gammopathies. We report a case of a 71 year old lady with a history of chronic gastritis and recurrent lower respiratory tract infection whereby no specific diagnosis was made until a computed tomography (CT) guided lung biopsy and orogastroduodenoscopy (OGDS) 5 years later from the onset of initial symptoms revealed pulmonary and gastric amyloidosis, respectively.

    Original languageEnglish
    Pages (from-to)51-55
    Number of pages5
    JournalMalaysian Journal of Medicine and Health Sciences
    Volume7
    Issue number1
    Publication statusPublished - Jan 2011

    Fingerprint

    Paraproteinemias
    Amyloidosis
    Immunoglobulins
    Paraproteins
    Immunoglobulin Light Chains
    Lung
    Immunoglobulin Isotypes
    Gastritis
    Plasma Cells
    Respiratory Tract Infections
    Stomach
    Proteins
    B-Lymphocytes
    Clone Cells
    Immunoglobulin G
    Tomography
    Biopsy
    Light

    Keywords

    • Amyloidosis
    • Heavy chain Ig
    • Light chain immunoglobulin (Ig)
    • Monoclonal gammopathies
    • Paraprotein

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Monoclonal gammopathy with systemic amyloidosis : An evaluation of diagnostic elements. / Subashini, C. T.; George, E.; Nor Aini, U.

    In: Malaysian Journal of Medicine and Health Sciences, Vol. 7, No. 1, 01.2011, p. 51-55.

    Research output: Contribution to journalArticle

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