Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line

Muhammad Aliyu, Oyeronke A. Odunola, Ahsana D. Farooq, Huma Rasheed, Osman Mesaik Mohammed Ahmed Hassan, Muhammad I. Choudhary, Iffat S. Channa, Salman A. Khan, Ochuko L. Erukainure

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Lung cancer is one of the leading causes of death worldwide. We investigated the molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cells by cell cycle, viability, cytokines, calcium ion and gene expression analysis. Acacia honey inhibited cells proliferation, arrested G0/G1 phase, stimulated cytokines, calcium ion release as well as suppressed p53 and Bcl-2 expression in a dose-dependent manner. We proposed that the molecular mechanism of the antiproliferation potential of Acacia honey on NCI-H460 cell line is due to cell cycle arrest, stimulation of cytokines and calcium ion as well as downregulation of Bcl-2 and p53 genes.

Original languageEnglish
Pages (from-to)296-304
Number of pages9
JournalNutrition and Cancer
Volume65
Issue number2
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Acacia
Honey
Ions
Cytokines
Calcium
Cell Line
bcl-2 Genes
Cell Cycle Resting Phase
p53 Genes
G1 Phase
Cell Cycle Checkpoints
Cause of Death
Lung Neoplasms
Cell Survival
Cell Cycle
Down-Regulation
Cell Proliferation
Gene Expression

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research

Cite this

Aliyu, M., Odunola, O. A., Farooq, A. D., Rasheed, H., Mohammed Ahmed Hassan, O. M., Choudhary, M. I., ... Erukainure, O. L. (2013). Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line. Nutrition and Cancer, 65(2), 296-304. https://doi.org/10.1080/01635581.2013.756920

Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line. / Aliyu, Muhammad; Odunola, Oyeronke A.; Farooq, Ahsana D.; Rasheed, Huma; Mohammed Ahmed Hassan, Osman Mesaik; Choudhary, Muhammad I.; Channa, Iffat S.; Khan, Salman A.; Erukainure, Ochuko L.

In: Nutrition and Cancer, Vol. 65, No. 2, 2013, p. 296-304.

Research output: Contribution to journalArticle

Aliyu, M, Odunola, OA, Farooq, AD, Rasheed, H, Mohammed Ahmed Hassan, OM, Choudhary, MI, Channa, IS, Khan, SA & Erukainure, OL 2013, 'Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line', Nutrition and Cancer, vol. 65, no. 2, pp. 296-304. https://doi.org/10.1080/01635581.2013.756920
Aliyu M, Odunola OA, Farooq AD, Rasheed H, Mohammed Ahmed Hassan OM, Choudhary MI et al. Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line. Nutrition and Cancer. 2013;65(2):296-304. https://doi.org/10.1080/01635581.2013.756920
Aliyu, Muhammad ; Odunola, Oyeronke A. ; Farooq, Ahsana D. ; Rasheed, Huma ; Mohammed Ahmed Hassan, Osman Mesaik ; Choudhary, Muhammad I. ; Channa, Iffat S. ; Khan, Salman A. ; Erukainure, Ochuko L. / Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line. In: Nutrition and Cancer. 2013 ; Vol. 65, No. 2. pp. 296-304.
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