Molecular biology of Macrobrachium rosenbergii nodavirus infection in giant freshwater prawn

Low Chen Fei, Mohd Radzi Md Yusoff, Giva Kuppusamy, Nur Farahiyah Ahmad Nadzri

Research output: Contribution to journalArticle

Abstract

Macrobrachium rosenbergii nodavirus (MrNV) has been threatening the giant freshwater prawn aquaculture since 1997, causing white tail disease in the prawn species that leads to 100% lethality of the infected postlarvae. Comprehension of the viral infectivity and pathogenesis at molecular biology level has recently resolved the viral capsid protein and evidenced the significant difference in the viral structural protein compared to other nodaviruses that infect fish and insect. Cumulative researches have remarked the proposal to assert MrNV as a member of new genus, gammanodavirus to the Nodaviridae family. The significance of molecular biology in MrNV infection is being highlighted in this current review, revolving the viral life cycle from virus binding and entry into host, virus replication in host cell, to virus assembly and release. The current review also highlights the emerging aptamers technology that is also known as synthetic antibody, its application in disease diagnosis, and its prophylactic and therapeutic properties. The future perspective of synthetic virology technology in understanding viral pathogenesis, as well as its potential in viral vaccine development, is also discussed.

Original languageEnglish
JournalJournal of Fish Diseases
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

Nodaviridae
Palaemonidae
Macrobrachium rosenbergii
Fresh Water
molecular biology
Molecular Biology
virus
Infection
infection
Viral Vaccines
viral proteins
Viral Structural Proteins
Technology
Virus Release
Virus Attachment
Virus Assembly
Virus Internalization
Aquaculture
Virology
protein

Keywords

  • apoptosis
  • Macrobrachium rosenbergii nodavirus
  • molecular biology
  • pathogenesis
  • virus life cycle

ASJC Scopus subject areas

  • Aquatic Science
  • veterinary (miscalleneous)

Cite this

Molecular biology of Macrobrachium rosenbergii nodavirus infection in giant freshwater prawn. / Chen Fei, Low; Md Yusoff, Mohd Radzi; Kuppusamy, Giva; Ahmad Nadzri, Nur Farahiyah.

In: Journal of Fish Diseases, 01.01.2018.

Research output: Contribution to journalArticle

Chen Fei, Low ; Md Yusoff, Mohd Radzi ; Kuppusamy, Giva ; Ahmad Nadzri, Nur Farahiyah. / Molecular biology of Macrobrachium rosenbergii nodavirus infection in giant freshwater prawn. In: Journal of Fish Diseases. 2018.
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