Modulation of gastric motility and gastric lesion formation in stressed rats given enteral supplementation of palm vitamin e and α-tocopherol

Ibrahim Abdel Aziz Ibrahim, Kamisah Yusof, Mohd Ismail Nafeeza, Nur Azlina Mohd Fahami

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: Stress is one of the major factors that cause various pathological changes in the gastrointestinal tract. The present study investigated the effects of palm vitamin E (PVE) and ¿-tocopherol (¿-TF) on gastric motility using water-immersion restraint stress (WRS) model. Design: Sixty male Sprague-Dawley rats (200-250 gm) were divided to three equal size groups; a control group was given a normal diet, second group administered 60 mg/kg/d of PVE or vehicle only for 28 days. Another group of rats receiving ¿-TF was also included for comparison. At the end of the treatment period, half of the rats from each group were subjected to WRS for 3.5 hours. Blood was sampled to measure the level of acetylcholine (ACh) product after which the measurement of gastric motility by electrogastrogram was carried out. The rats were sacrificed and the stomachs were then examined for lesions. Results: WRS increased plasma ACh product levels, gastric motility and lesions. PVE or ¿-TF was able to reduce ACh product levels, gastric motility and lesions. Conclusion: PVE and ¿-TF were able to reduce the gastric lesions possibly by blocking the increase in the ACh level and gastric motility induced by stress.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalInternational Medical Journal
Volume18
Issue number1
Publication statusPublished - Mar 2011

Fingerprint

Tocopherols
Vitamins
Small Intestine
Stomach
Vitamin E
Acetylcholine
Immersion
Water
Sprague Dawley Rats
Gastrointestinal Tract
Diet
Control Groups

Keywords

  • ¿-tocopherol
  • Acetylcholine
  • Gastric lesions
  • Gastric motility
  • Palm vitamin E
  • Water-immersion restraint stress

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Modulation of gastric motility and gastric lesion formation in stressed rats given enteral supplementation of palm vitamin e and α-tocopherol. / Ibrahim, Ibrahim Abdel Aziz; Yusof, Kamisah; Nafeeza, Mohd Ismail; Mohd Fahami, Nur Azlina.

In: International Medical Journal, Vol. 18, No. 1, 03.2011, p. 47-52.

Research output: Contribution to journalArticle

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