Modification of initial highly active antiretroviral therapy (HAART) regimen in paediatric HIV patients

Yee Shan Low, Farida Hanim Islahudin, Kamarul Azahar Mohd Razali, Shafnah Adnan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Treatment options among Human Immunodeficiency Virus (HIV)-infected children are limited as only a few Highly Active Antiretroviral Therapy (HAART) are approved worldwide for paediatric use. Among children, frequent changes in HAART regimen can rapidly exhaust treatment options, and information addressing this issue is scarce. Objective: The aim of the study was to determine factors associated with the modification of initial HAART regimen modification among HIV-infected children. Method: A retrospective study was performed among HIV-infected children aged 18 and below, that received HAART for at least six months in a tertiary hospital in Malaysia. Factors associated with modification of initial HAART regimen were investigated. Results: Out of 99 patients, 71.1% (n=71) required initial HAART regime modification. The most common reason for HAART modification was treatment failure (n=39, 54.9%). Other reasons included drug toxicity (n=14, 19.7%), change to fixed-dose products (n=11, 15.5%), product discontinuation (n=4, 5.6%) and intolerable taste (n=3, 4.2%). The overall mean time retention on initial HAART before regimen modification was 3.32 year ± 2.24 years (95% CI, 2.79–3.85). Patient's adherence was the only factor associated with initial regimen modification in this study. Participants with poor adherence showed a five-fold risk of having their initial HAART regimen modified compared to those with good adherence (adjusted OR [95% CI], 5.250 [1.614 – 17.076], p = 0.006). Conclusion: Poor adherence was significantly associated with initial regimen modification, intervention to improve patient's adherence is necessary to prevent multiple regimen modification among HIV-infected children.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalOpen AIDS Journal
Volume12
DOIs
Publication statusPublished - 12 Mar 2018

Fingerprint

Highly Active Antiretroviral Therapy
HIV
Pediatrics
Patient Compliance
Malaysia
Drug-Related Side Effects and Adverse Reactions
Treatment Failure
Tertiary Care Centers
Retrospective Studies
Therapeutics

Keywords

  • HAART
  • Highly active antiretroviral therapy
  • HIV
  • Intolerable taste
  • Malaysia
  • Paediatric
  • Regimen modification

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Virology

Cite this

Modification of initial highly active antiretroviral therapy (HAART) regimen in paediatric HIV patients. / Low, Yee Shan; Islahudin, Farida Hanim; Razali, Kamarul Azahar Mohd; Adnan, Shafnah.

In: Open AIDS Journal, Vol. 12, 12.03.2018, p. 11-19.

Research output: Contribution to journalArticle

Low, Yee Shan ; Islahudin, Farida Hanim ; Razali, Kamarul Azahar Mohd ; Adnan, Shafnah. / Modification of initial highly active antiretroviral therapy (HAART) regimen in paediatric HIV patients. In: Open AIDS Journal. 2018 ; Vol. 12. pp. 11-19.
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