Modifiable factors associated with bone health in Malaysian adolescents utilising calcaneus quantitative ultrasound

Mohamed S. Zulfarina, Razinah Sharif @ Mohd Sharif, Syed Badrul Syarifah-Noratiqah, Ahmad M. Sharkawi, Zaris SM Aqilah, Sabarul Afian Mokhtar, Ahmad Nazrun Shuid, Isa Naina Mohamed

Research output: Contribution to journalArticle

Abstract

Maximizing bone mineral accrual to attain an optimal peak bone mass (PBM), particularly during adolescence, appears to be an effective protective strategy in the prevention of osteoporosis. This study aimed to evaluate the influence of physical activity (PA), fat mass (FM), lean mass (LM), body mass index (BMI), calcium, or combination of vitamin D supplement intake, smoking and alcohol drinking status on bone health assessed by calcaneus quantitative ultrasound (QUS) in a healthy adolescent population. The participants comprised of 920 male and female secondary school adolescents aged 15–17 years old. Quantitative ultrasound measurements of the left heel were performed using Lunar Achilles EX II, which included results of broadband ultrasound attenuation (BUA), speed of sound (SOS), and a calculated stiffness index (SI). Multivariable linear regression analyses revealed that—PA was positively associated with all three QUS indices in both genders; BMI was positively associated with SI and SOS in females; LM was positively associated with BUA in both genders; and FM was negatively associated with SI in females. These variables accounted for 32.1%, 21.2% and 29.4% of females’ SOS, BUA and SI variances (p<0.001), respectively and 23.6%, 15.4% and 17.2% of males’ SOS, BUA and SI variances (p<0.001), respectively. Promoting health benefits from physical activity could influence bone status and consequently improve PBM, which is a potent protective determinant against osteoporosis in adulthood.

Original languageEnglish
Article numbere0202321
JournalPLoS One
Volume13
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

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Calcaneus
Bone
Ultrasonics
bones
Health
Bone and Bones
Acoustic wave velocity
Stiffness
osteoporosis
Osteoporosis
Body Mass Index
physical activity
Fats
body mass index
Exercise
adolescence
Heel
Insurance Benefits
health promotion
Vitamin D

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Modifiable factors associated with bone health in Malaysian adolescents utilising calcaneus quantitative ultrasound. / Zulfarina, Mohamed S.; Sharif @ Mohd Sharif, Razinah; Syarifah-Noratiqah, Syed Badrul; Sharkawi, Ahmad M.; Aqilah, Zaris SM; Mokhtar, Sabarul Afian; Shuid, Ahmad Nazrun; Naina Mohamed, Isa.

In: PLoS One, Vol. 13, No. 8, e0202321, 01.08.2018.

Research output: Contribution to journalArticle

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