Modelling activation and connectivity in the brain: An fMRI study during externally triggered finger tapping task

Ahmad Nazlim Yusoff, Khairiah Abdul Hamid

Research output: Contribution to journalArticle

Abstract

Brain activation within and effective connectivity between two significantly activated left and right primary motor regions (M1 left and M1 right) were modelled using functional magnetic resonance imaging datasets of seven subjects obtained from an externally triggered unilateral and bilateral finger tapping experiment. Unilateral tapping exhibited contra lateral activation while bilateral tapping activated both the M1 left and M1 right regions. Unlike bilateral tapping that exhibited a relatively equal change of M1 left and M1 right signal at the coordinates of maximum intensity, the value is significantly lower in M1 left as compared to M1 right for unilateral tapping. The effective connectivity between M1 left and M1 right during bilateral tapping of hand fingers can be explained by a bilinear causal model, which is averagely preferred by five subjects (Dirichlet parameter estimate, α d ≈ 5). The regional connectivities are however not gated (influenced) by any of the two M1s, ruling out the possibility of the non-linear behavior of connections between both M1s. This study has been able to fit the effective connectivity between M1left and M1 right with a bilinear model that has the lowest free energy (F) of -644.70 and the largest likelihood (4.77 × 10 39), posterior (φ = 1.00), expected (r = 0.67) and exceedance (ψ = 0.92) probabilities.

Original languageEnglish
Pages (from-to)178-212
Number of pages35
JournalMalaysian Journal of Mathematical Sciences
Volume6
Issue number2
Publication statusPublished - Jul 2012

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Functional Magnetic Resonance Imaging
Activation
Connectivity
Bilinear Model
Modeling
Causal Model
Exceedance
Dirichlet
Free Energy
Lateral
Lowest
Likelihood
Brain
Estimate
Experiment

Keywords

  • Bayesian model selection
  • Bilinear model
  • Dynamic causal modeling
  • Exceedance probability
  • Expected probability

ASJC Scopus subject areas

  • Mathematics(all)

Cite this

Modelling activation and connectivity in the brain : An fMRI study during externally triggered finger tapping task. / Yusoff, Ahmad Nazlim; Hamid, Khairiah Abdul.

In: Malaysian Journal of Mathematical Sciences, Vol. 6, No. 2, 07.2012, p. 178-212.

Research output: Contribution to journalArticle

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