Modeling neck linker of kinesin motor movement with MRSR stochastic differential equation

Wan Qashishah Akmal Wan Razali, Siti Norafidah Mohd Ramli, Shahidan Radiman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Stochastic differential equation has a significant role in a range of biological areas including molecular motor like kinesin motor. Mean-reverting square root (MRSR) stochastic differential equation is commonly used in economics and finance areas. In this study, we use the MRSR stochastic differential equation to model neck linker motion of kinesin motor by considering the possibilities of rightward direction and occasionally in the leftward direction of kinesin movements. This neck linker docking model of kinesin motor incorporates the conformational change in the chemical kinetics and the tethered diffusion of the free head of kinesin motor. Here, we demonstrate this model by using Hookean spring method which referred to the stiffness model of neck linker. The motion of kinesin motor seems to be well described to move in unidirectional way with volatile behavior based on MRSR rather than common stochastic differential equation [DOI 10.1007/s11538-011-9697-6].

Original languageEnglish
Title of host publication2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium
PublisherAmerican Institute of Physics Inc.
Volume1784
ISBN (Electronic)9780735414464
DOIs
Publication statusPublished - 17 Nov 2016
Event2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016 - Selangor, Malaysia
Duration: 13 Apr 201614 Apr 2016

Other

Other2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016
CountryMalaysia
CitySelangor
Period13/4/1614/4/16

Fingerprint

differential equations
finance
economics
stiffness
reaction kinetics

Keywords

  • kinesin motor
  • Mean-reverting square root (MRSR)
  • Stochastic modeling
  • unidirectional motion

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Razali, W. Q. A. W., Mohd Ramli, S. N., & Radiman, S. (2016). Modeling neck linker of kinesin motor movement with MRSR stochastic differential equation. In 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium (Vol. 1784). [040022] American Institute of Physics Inc.. https://doi.org/10.1063/1.4966808

Modeling neck linker of kinesin motor movement with MRSR stochastic differential equation. / Razali, Wan Qashishah Akmal Wan; Mohd Ramli, Siti Norafidah; Radiman, Shahidan.

2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784 American Institute of Physics Inc., 2016. 040022.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Razali, WQAW, Mohd Ramli, SN & Radiman, S 2016, Modeling neck linker of kinesin motor movement with MRSR stochastic differential equation. in 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. vol. 1784, 040022, American Institute of Physics Inc., 2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016, Selangor, Malaysia, 13/4/16. https://doi.org/10.1063/1.4966808
Razali WQAW, Mohd Ramli SN, Radiman S. Modeling neck linker of kinesin motor movement with MRSR stochastic differential equation. In 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784. American Institute of Physics Inc. 2016. 040022 https://doi.org/10.1063/1.4966808
Razali, Wan Qashishah Akmal Wan ; Mohd Ramli, Siti Norafidah ; Radiman, Shahidan. / Modeling neck linker of kinesin motor movement with MRSR stochastic differential equation. 2016 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2016 Postgraduate Colloquium. Vol. 1784 American Institute of Physics Inc., 2016.
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