Mixed non-albicans Candida fungemia

An uncommon but easily overlooked clinical entity

Chuan Hun Ding, Zaili Zaki

Research output: Contribution to journalArticle

Abstract

The increasing use of invasive medical devices and broad-spectrum antimicrobial agents has resulted in rising candidemia rates throughout the world. A 70-year-old diabetic and schizophrenic woman was admitted initially for staphylococcal sepsis secondary to an infected sacral sore but developed a catheter-related bloodstream infection caused by extended-spectrum β-lactamase-producing Klebsiella sp. which necessitated the administration of meropenem. Unfortunately, after a week on the carbapenem, the bacterial sepsis was followed by candidemia. Parenteral fluconazole therapy was started pending identification of the yeast(s). Two distinct Candida species were isolated from her blood which were identified biochemically using ID 32 C as Candida tropicalis and Candida lipolytica. Both yeasts possessed elevated minimal inhibitory concentrations toward fluconazole and although amphotericin B was eventually administered, the patient succumbed to her illness.

Original languageEnglish
Pages (from-to)8-10
Number of pages3
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume11
Issue number11
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Fungemia
Candidemia
Fluconazole
meropenem
Candida
Sepsis
Yeasts
Candida tropicalis
Catheter-Related Infections
Carbapenems
Klebsiella
Amphotericin B
Anti-Infective Agents
Equipment and Supplies
Therapeutics

Keywords

  • Candida lipolytica
  • Candida tropicalis
  • Fluconazole
  • Non-albicans candida

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

Mixed non-albicans Candida fungemia : An uncommon but easily overlooked clinical entity. / Ding, Chuan Hun; Zaki, Zaili.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, No. 11, 01.01.2018, p. 8-10.

Research output: Contribution to journalArticle

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