Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

Mojtaba Golpich, Elham Amini, Zahurin Mohamed, Raymond Azman Ali, Norlinah Mohamed Ibrahim, Abolhassan Ahmadiani

Research output: Contribution to journalReview article

88 Citations (Scopus)

Abstract

Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and characterized by the progressive degeneration of the function and structure of the central nervous system (CNS) for reasons that are not yet understood. Neurodegeneration is the umbrella term for the progressive death of nerve cells and loss of brain tissue. Because of their high energy requirements, neurons are especially vulnerable to injury and death from dysfunctional mitochondria. Widespread damage to mitochondria causes cells to die because they can no longer produce enough energy. Several lines of pathological and physiological evidence reveal that impaired mitochondrial function and dynamics play crucial roles in aging and pathogenesis of neurodegenerative diseases. As mitochondria are the major intracellular organelles that regulate both cell survival and death, they are highly considered as a potential target for pharmacological-based therapies. The purpose of this review was to present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) and the importance of mitochondrial biogenesis as a potential novel therapeutic target for their treatment. Likewise, we highlight a concise overview of the key roles of mitochondrial electron transport chain (ETC.) complexes as well as mitochondrial biogenesis regulators regarding those diseases.

Original languageEnglish
Pages (from-to)5-22
Number of pages18
JournalCNS Neuroscience and Therapeutics
Volume23
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Fingerprint

Organelle Biogenesis
Neurodegenerative Diseases
Mitochondria
Mitochondrial Dynamics
Neurons
Huntington Disease
Amyotrophic Lateral Sclerosis
Electron Transport
Organelles
Parkinson Disease
Cell Survival
Alzheimer Disease
Cell Death
Central Nervous System
Pharmacology
Wounds and Injuries
Brain
Therapeutics

Keywords

  • Mitochondrial Biogenesis
  • Mitochondrial complexes
  • Mitochondrial Dysfunction
  • Neurodegenerative Diseases
  • Pathogenesis
  • Treatment

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Physiology (medical)
  • Pharmacology (medical)

Cite this

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases : Pathogenesis and Treatment. / Golpich, Mojtaba; Amini, Elham; Mohamed, Zahurin; Ali, Raymond Azman; Mohamed Ibrahim, Norlinah; Ahmadiani, Abolhassan.

In: CNS Neuroscience and Therapeutics, Vol. 23, No. 1, 01.01.2017, p. 5-22.

Research output: Contribution to journalReview article

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