miRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis

Chiranjib Chakraborty, Kok Yong Chin, Srijit Das

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. We also described the migration and tumor formation. Finally, we described the different miRNAs that regulate various types of cancer stem cells, such as prostate cancer stem cells, head and neck cancer stem cells, breast cancer stem cells, colorectal cancer stem cells, lung cancer stem cells, gastric cancer stem cells, pancreatic cancer stem cells, etc. Extensive research is needed in order to employ miRNA-based therapeutics to control cancer stem cell population in various cancers in the future.

Original languageEnglish
Pages (from-to)13039-13048
Number of pages10
JournalTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Volume37
Issue number10
DOIs
Publication statusPublished - 1 Oct 2016

Fingerprint

Neoplastic Stem Cells
MicroRNAs
Carcinogenesis
Population
Neoplasms
Head and Neck Neoplasms
Pancreatic Neoplasms
Stomach Neoplasms
Colorectal Neoplasms
Lung Neoplasms
Prostatic Neoplasms
Stem Cells

Keywords

  • Migration
  • miRNA
  • Stem cell
  • Therapy
  • Tumor

ASJC Scopus subject areas

  • Cancer Research

Cite this

@article{50a2b7ffce3744d6948f15eac23df80a,
title = "miRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis",
abstract = "Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. We also described the migration and tumor formation. Finally, we described the different miRNAs that regulate various types of cancer stem cells, such as prostate cancer stem cells, head and neck cancer stem cells, breast cancer stem cells, colorectal cancer stem cells, lung cancer stem cells, gastric cancer stem cells, pancreatic cancer stem cells, etc. Extensive research is needed in order to employ miRNA-based therapeutics to control cancer stem cell population in various cancers in the future.",
keywords = "Migration, miRNA, Stem cell, Therapy, Tumor",
author = "Chiranjib Chakraborty and Chin, {Kok Yong} and Srijit Das",
year = "2016",
month = "10",
day = "1",
doi = "10.1007/s13277-016-5156-1",
language = "English",
volume = "37",
pages = "13039--13048",
journal = "Tumor Biology",
issn = "1010-4283",
publisher = "Springer Netherlands",
number = "10",

}

TY - JOUR

T1 - miRNA-regulated cancer stem cells

T2 - understanding the property and the role of miRNA in carcinogenesis

AU - Chakraborty, Chiranjib

AU - Chin, Kok Yong

AU - Das, Srijit

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. We also described the migration and tumor formation. Finally, we described the different miRNAs that regulate various types of cancer stem cells, such as prostate cancer stem cells, head and neck cancer stem cells, breast cancer stem cells, colorectal cancer stem cells, lung cancer stem cells, gastric cancer stem cells, pancreatic cancer stem cells, etc. Extensive research is needed in order to employ miRNA-based therapeutics to control cancer stem cell population in various cancers in the future.

AB - Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. We also described the migration and tumor formation. Finally, we described the different miRNAs that regulate various types of cancer stem cells, such as prostate cancer stem cells, head and neck cancer stem cells, breast cancer stem cells, colorectal cancer stem cells, lung cancer stem cells, gastric cancer stem cells, pancreatic cancer stem cells, etc. Extensive research is needed in order to employ miRNA-based therapeutics to control cancer stem cell population in various cancers in the future.

KW - Migration

KW - miRNA

KW - Stem cell

KW - Therapy

KW - Tumor

UR - http://www.scopus.com/inward/record.url?scp=85012008724&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012008724&partnerID=8YFLogxK

U2 - 10.1007/s13277-016-5156-1

DO - 10.1007/s13277-016-5156-1

M3 - Review article

C2 - 27468722

AN - SCOPUS:84979986065

VL - 37

SP - 13039

EP - 13048

JO - Tumor Biology

JF - Tumor Biology

SN - 1010-4283

IS - 10

ER -