Microorganisms Responsible for Onychomycosis Among Diabetic Patients

Translated title of the contribution: Mikroganisama penyebab jangkitan kulat kuku kalangan pesakit kencing manis

Leelavathi Muthupalani, Noor Azimah Muhammad, N. F. Kharuddin, M. N. Tzarar

Research output: Contribution to journalArticle

Abstract

Diabetic patients are susceptible to infections due to compromised immune system. Among common infections include fungal infection of the nail, also known as onychomycosis. A cross sectional study was done to determine the prevalence and the common fungal element responsible of onychomycosis among patients with types 1 and 2 diabetes at the Pusat Perubatan Primer, Universiti Kebangsaan Malaysia. This study was conducted from October 2010 to May 2011. Nail clippings were taken from discolored or structurally abnormal toenail and from the right first toe nail if the nail appeared normal. The nail was first cleaned using 70% alcohol then clipped into small pieces using nail clipper. Nail sample was processed within 2 h of collection for microscopic examination using potassium hydroxide (KOH) and cultured on sabouraud dextrose agar. A total of 78 (51.7%) female and 73 (48.3%) male patients participated in this study. Most (60.3%, n=91) of them belong to Malay ethnic group followed by Chinese (24.5%, n=37), Indian (13.9%, n=21) and other (1.3%, n=2) ethnicities. The prevalence of onychomycosis among subjects was 81.5%. The most commonly isolated fungi from diabetic patient's toenails were non-dermatophyte moulds (39.7%, n=60,) especially Aspergillus (12.6%, n=19) followed by yeast (20.5%, n=31) and dermatophytes (0.7%, n=1). In contrast, Western studies demonstrate dermatophytes and yeasts as organisms commonly responsible for onychomycosis among diabetics. In conclusion, the prevalence of onychomycosis among diabetics is high hence they are at high risk of developing diabetic foot complications and amputations. The common causative microorganism for onychomycosis among diabetics in this study is non-dermatophyte mould.

Original languageUndefined/Unknown
Pages (from-to)359-363
Number of pages5
JournalSains Malaysiana
Volume42
Issue number3
Publication statusPublished - Mar 2013

Fingerprint

Nails
Onychomycosis
Arthrodermataceae
Fungi
Yeasts
Diabetic Foot
Mycoses
Malaysia
Toes
Diabetes Complications
Aspergillus
Infection
Type 1 Diabetes Mellitus
Amputation
Ethnic Groups
Type 2 Diabetes Mellitus
Agar
Immune System
Cross-Sectional Studies
Alcohols

Keywords

  • Diabetes
  • Fungus
  • Non-dermatophyte mould
  • Onychomycosis

ASJC Scopus subject areas

  • General

Cite this

Microorganisms Responsible for Onychomycosis Among Diabetic Patients. / Muthupalani, Leelavathi; Muhammad, Noor Azimah; Kharuddin, N. F.; Tzarar, M. N.

In: Sains Malaysiana, Vol. 42, No. 3, 03.2013, p. 359-363.

Research output: Contribution to journalArticle

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