Microwaved bacterial cellulose-based hydrogel microparticles for the healing of partial thickness burn wounds

Manisha Pandey, Najwa Mohamad, Wan Li Low, Claire Martin, Mohd Cairul Iqbal Mohd Amin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Burn wound management is a complex process because the damage may extend as far as the dermis which has an acknowledged slow rate of regeneration. This study investigates the feasibility of using hydrogel microparticles composed of bacterial cellulose and polyacrylamide as a dressing material for coverage of partial-thickness burn wounds. The microparticulate carrier structure and surface morphology were investigated by Fourier transform infrared, X-ray diffraction, elemental analysis, and scanning electron microscopy. The cytotoxicity profile of the microparticles showed cytocompatibility with L929 cells. Dermal irritation test demonstrated that the hydrogel was non-irritant to the skin and had a significant effect on wound contraction compared to the untreated group. Moreover, histological examination of in vivo burn healing samples revealed that the hydrogel treatment enhanced epithelialization and accelerated fibroblast proliferation with wound repair and intact skin achieved by the end of the study. Both the in vitro and in vivo results proved the biocompatibility and efficacy of hydrogel microparticles as a wound dressing material.

Original languageEnglish
Pages (from-to)89-99
Number of pages11
JournalDrug Delivery and Translational Research
Volume7
Issue number1
DOIs
Publication statusPublished - 1 Feb 2017

Fingerprint

Hydrogel
Cellulose
Wounds and Injuries
Bandages
Infrared Rays
Skin
Feasibility Studies
Fourier Analysis
Dermis
Skin Tests
X-Ray Diffraction
Electron Scanning Microscopy
Regeneration
Fibroblasts

Keywords

  • Bacterial cellulose
  • Cytotoxicity
  • Hydrogel microparticles
  • Microwave irradiation
  • Partial-thickness burn wound

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Microwaved bacterial cellulose-based hydrogel microparticles for the healing of partial thickness burn wounds. / Pandey, Manisha; Mohamad, Najwa; Low, Wan Li; Martin, Claire; Mohd Amin, Mohd Cairul Iqbal.

In: Drug Delivery and Translational Research, Vol. 7, No. 1, 01.02.2017, p. 89-99.

Research output: Contribution to journalArticle

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