Sintesis partikel nano silika berliang meso dibantu gelombang mikro sebagai medium penyebaran ubat

Translated title of the contribution: Microwave-assisted synthesis of mesoporous silica nanoparticles as a drug delivery vehicle

Kamarudin Nur Hidayatul Nazirah, Aishah Abdul Jalil, Sugeng Triwahyono, Timmiati Sharifah Najiha

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Nanotechnology has been utilized in medicine for therapeutic drug delivery and the development of treatments for a variety of diseases and disorders. Mesoporous silica nanoparticles (MSN), which combine both unique properties of nanomaterials and mesostructured substances, have aroused special attention in biomedical research field due to its great advantages in many aspects such as well biocompatible, unique properties of tunable pore size and structure, large surface areas and pore volumes, controllable morphology and modifiable surfaces, high chemical and thermal stabilities. In this study, the microwave was utilized to synthesize MSN under 100 W, 300 W and 450 W heating powers. All MSNs was tested for adsorption and release of an anti-inflammatory and anti-cancer drug, ibuprofen. The characterization revealed that the MSN prepared under 450 W (MSN450) produced the most ordered and prominent mesoporous structure compared to lower power applied. MSN450 exhibited the highest ibuprofen adsorption, followed by MSN300 and MSN100, confirming that more ordered MSN demonstrated higher adsorptivity toward ibuprofen. For the release study, MSN450 showed the slowest release rate of ibuprofen, followed by MSN300 and MSN100. All MSNs was found to exhibit good activity for the ibuprofen adsorption and release.

Original languageMalay
Pages (from-to)1382-1389
Number of pages8
JournalMalaysian Journal of Analytical Sciences
Volume20
Issue number6
DOIs
Publication statusPublished - 2016

Fingerprint

Ibuprofen
Drug delivery
Silicon Dioxide
Microwaves
Nanoparticles
Adsorption
Chemical stability
Pore structure
Nanotechnology
Nanostructured materials
Medicine
Pore size
Thermodynamic stability
Anti-Inflammatory Agents
Heating
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Sintesis partikel nano silika berliang meso dibantu gelombang mikro sebagai medium penyebaran ubat. / Nur Hidayatul Nazirah, Kamarudin; Jalil, Aishah Abdul; Triwahyono, Sugeng; Sharifah Najiha, Timmiati.

In: Malaysian Journal of Analytical Sciences, Vol. 20, No. 6, 2016, p. 1382-1389.

Research output: Contribution to journalArticle

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