MicroRNAs and lymph node metastasis in papillary thyroid cancers

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Lymph node metastasis (LNM) in papillary thyroid cancer (PTC) has been shown to be associated with increased risk of locoregional recurrence, poor prognosis and decreased survival, especially in older patients. Hence, there is a need for a reliable biomarker for the prediction of LNM in this cancer. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene translation or degradation and play key roles in numerous cellular functions including cell-cycle regulation, differentiation, apoptosis, invasion and migration. Various studies have demonstrated deregulation of miRNA levels in many diseases including cancers. While a large number of miRNAs have been identified from PTCs using various means, association of miRNAs with LNM in such cases is still controversial. Furthermore, studies linking most of the identified miRNAs to the mechanism of LNM have not been well documented. The aim of this review is to update readers on the current knowledge of miRNAs in relation to LNM in PTC.

Original languageEnglish
Pages (from-to)25-35
Number of pages11
JournalAsian Pacific Journal of Cancer Prevention
Volume17
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

MicroRNAs
Lymph Nodes
Neoplasm Metastasis
Small Untranslated RNA
Factor IX
Papillary Thyroid cancer
Neoplasms
Cell Cycle
Biomarkers
Apoptosis
Recurrence
Survival
Genes

Keywords

  • Biomarker
  • Lymph node
  • Metastasis
  • microRNAs
  • Papillary thyroid cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

MicroRNAs and lymph node metastasis in papillary thyroid cancers. / Ab Mutalib, Nurul Syakima; Yusof, Azliana Mohamad; Mohd Mokhtar, Norfilza; Harun, Roslan; Muhammad, Rohaizak; A. Jamal, A. Rahman.

In: Asian Pacific Journal of Cancer Prevention, Vol. 17, No. 1, 2016, p. 25-35.

Research output: Contribution to journalArticle

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AU - Muhammad, Rohaizak

AU - A. Jamal, A. Rahman

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AB - Lymph node metastasis (LNM) in papillary thyroid cancer (PTC) has been shown to be associated with increased risk of locoregional recurrence, poor prognosis and decreased survival, especially in older patients. Hence, there is a need for a reliable biomarker for the prediction of LNM in this cancer. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene translation or degradation and play key roles in numerous cellular functions including cell-cycle regulation, differentiation, apoptosis, invasion and migration. Various studies have demonstrated deregulation of miRNA levels in many diseases including cancers. While a large number of miRNAs have been identified from PTCs using various means, association of miRNAs with LNM in such cases is still controversial. Furthermore, studies linking most of the identified miRNAs to the mechanism of LNM have not been well documented. The aim of this review is to update readers on the current knowledge of miRNAs in relation to LNM in PTC.

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