Microneedles for intradermal and transdermal drug delivery

Tuan Mazlelaa Tuan Mahmood, Maelíosa T C McCrudden, Barbara M. Torrisi, Emma McAlister, Martin J. Garland, Thakur Raghu Raj Singh, Ryan F. Donnelly

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The formidable barrier properties of the uppermost layer of the skin, the stratum corneum, impose significant limitations for successful systemic delivery of broad range of therapeutic molecules particularly macromolecules and genetic material. Microneedle (MN) has been proposed as a strategy to breach the stratum corneum barrier function in order to facilitate effective transport of molecules across the skin. This strategy involves use of micron sized needles fabricated of different materials and geometries to create transient aqueous conduits across the skin. MN, alone or with other enhancing strategies, has been demonstrated to dramatically enhance the skin permeability of numerous therapeutic molecules including biopharmaceuticals either in vitro, ex vivo or in vivo experiments. This suggested the promising use of MN technology for various possible clinical applications such as insulin delivery, transcutaneous immunisations and cutaneous gene delivery. MN has been proved as minimally invasive and painless in human subjects. This review article focuses on recent and future developments for MN technology including the latest type of MN design, challenges and strategies in MNs development as well as potential safety aspects based on comprehensive literature review pertaining to MN studies to date.

Original languageEnglish
Pages (from-to)623-637
Number of pages15
JournalEuropean Journal of Pharmaceutical Sciences
Volume50
Issue number5
DOIs
Publication statusPublished - 2013

Fingerprint

Skin
Pharmaceutical Preparations
Cornea
Technology
Genes
Needles
Immunization
Permeability
Insulin
Safety
Therapeutics

Keywords

  • Drug monitoring
  • Hydrogel-forming
  • Microneedle
  • Safety
  • Transdermal drug delivery
  • Vaccination

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Tuan Mahmood, T. M., McCrudden, M. T. C., Torrisi, B. M., McAlister, E., Garland, M. J., Singh, T. R. R., & Donnelly, R. F. (2013). Microneedles for intradermal and transdermal drug delivery. European Journal of Pharmaceutical Sciences, 50(5), 623-637. https://doi.org/10.1016/j.ejps.2013.05.005

Microneedles for intradermal and transdermal drug delivery. / Tuan Mahmood, Tuan Mazlelaa; McCrudden, Maelíosa T C; Torrisi, Barbara M.; McAlister, Emma; Garland, Martin J.; Singh, Thakur Raghu Raj; Donnelly, Ryan F.

In: European Journal of Pharmaceutical Sciences, Vol. 50, No. 5, 2013, p. 623-637.

Research output: Contribution to journalArticle

Tuan Mahmood, TM, McCrudden, MTC, Torrisi, BM, McAlister, E, Garland, MJ, Singh, TRR & Donnelly, RF 2013, 'Microneedles for intradermal and transdermal drug delivery', European Journal of Pharmaceutical Sciences, vol. 50, no. 5, pp. 623-637. https://doi.org/10.1016/j.ejps.2013.05.005
Tuan Mahmood, Tuan Mazlelaa ; McCrudden, Maelíosa T C ; Torrisi, Barbara M. ; McAlister, Emma ; Garland, Martin J. ; Singh, Thakur Raghu Raj ; Donnelly, Ryan F. / Microneedles for intradermal and transdermal drug delivery. In: European Journal of Pharmaceutical Sciences. 2013 ; Vol. 50, No. 5. pp. 623-637.
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