Micro-CT assessments of potential anti-osteoporotic agents

Nadia Mohd Effendy, Mohd Fadhli Khamis, Ahmad Nazrun Shuid

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Bone quality assessment is important in assessments of potential agents for the prevention and treatment of osteoporosis. Bone density, microarchitecture and strength are important determinants in osteoporotic study which are widely studied using Dual-Energy X-ray Absorptiometry (DXA), histomorphometry and radiological imaging techniques. In recent years, high resolution micro-CT has become feasible for in vitro or in vivo evaluation of bone architecture. Three-dimensional images of micro-CT reflected high correlations with the conventional histomorphometry and DXA. In comparison to other imaging techniques, micro-CT is the most effective tool in detecting early bone changes for fracture prediction and assessments of potential anti-osteoporotic agents. It is crucial to define an ideal setting with safe radiation doses and appropriate methods for image reconstruction and segmentation to obtain high resolution images. Micro-CT evaluation provides a better insight of bone structure as well as non-metric parameters such as connectivity density, structural model index (SMI) and degree of anisotropy (DA). This non-invasive imaging technique is also equipped with finite element analysis for evaluation of bone biomechanical strength. Micro-CT allows a compressive understanding of the relationships between bone density, microarchitecture and strength which is fundamental to development of pharmacological interventions.

Original languageEnglish
Pages (from-to)1542-1551
Number of pages10
JournalCurrent Drug Targets
Volume14
Issue number13
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Bone
Bone and Bones
Photon Absorptiometry
Bone Density
Finite Element Analysis
Computer-Assisted Image Processing
Three-Dimensional Imaging
Structural Models
Imaging techniques
Anisotropy
Bone Fractures
Osteoporosis
X rays
Pharmacology
Radiation
Image resolution
Image reconstruction
Image segmentation
Dosimetry
Finite element method

Keywords

  • Anti-osteoporotic agents
  • Bone architecture
  • Bone quality
  • Micro-CT
  • Osteoporosis
  • Radiology

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Micro-CT assessments of potential anti-osteoporotic agents. / Effendy, Nadia Mohd; Khamis, Mohd Fadhli; Shuid, Ahmad Nazrun.

In: Current Drug Targets, Vol. 14, No. 13, 12.2013, p. 1542-1551.

Research output: Contribution to journalArticle

Effendy, Nadia Mohd ; Khamis, Mohd Fadhli ; Shuid, Ahmad Nazrun. / Micro-CT assessments of potential anti-osteoporotic agents. In: Current Drug Targets. 2013 ; Vol. 14, No. 13. pp. 1542-1551.
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