Methods of cystic duct occlusion during laparoscopic cholecystectomy.

Kurinchi Selvan Gurusamy, Jin J. Bong, Giuseppe Fusai, Brian R. Davidson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

During laparoscopic cholecystectomy, it is necessary to occlude the cystic duct permanently. Traditionally, this has been performed through the application of non-absorbable metal clips. Use of absorbable materials to occlude the cystic duct has been suggested as an alternative for metal clips for various reasons. To assess the benefits and harms of the different methods of occlusion of cystic duct in patients undergoing laparoscopic cholecystectomy. We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, The Cochrane Central Register of Controlled Trials in The Cochrane Library, MEDLINE, EMBASE, and Science Citation Index Expanded until August 2010. We included all randomised clinical trials comparing different methods of occlusion of cystic duct. We collected the data on the characteristics, methodological quality, bile duct injury, bile leaks, operating time, and incidence of recurrent common bile duct stone from each trial. We analysed the data with both the fixed-effect and the random-effects model using RevMan Analysis. For each outcome we calculated the risk ratio (RR) in the presence of more than one trial for the outcome or mean difference (MD) with 95% confidence intervals (CI) based on intention-to-treat analysis. In the presence of only one trial under a dichotomous outcome, we performed the Fisher's exact test. Three trials including 255 patients qualified for this review. In two of the trial, a total of 150 patients were randomised to absorbable clips (n = 75) and non-absorbable clips (n = 75). In the third trial, a total of 105 patients were randomised to absorbable ligatures (n = 53) and non-absorbable clips (n = 52). All three trials were of high risk of bias. There was no difference in the morbidity between the groups. There was statistically significant longer operating time (MD 12.00 minutes, 95% CI 1.59 to 22.41) in the absorbable ligature group than non-absorbable clips. The duration and method of follow-up were not adequate to determine the incidence of long-term complications. We are unable to determine the benefits and harms of different methods of cystic duct occlusion because of the small sample size, short period of follow-up, and lack of reporting of important outcomes in the included trials. Adequately powered randomised trials with low risk of bias and with long periods of follow-up and assessing all of the important outcomes for patients and professionals are necessary.

Original languageEnglish
JournalCochrane database of systematic reviews (Online)
Issue number10
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Cystic Duct
Laparoscopic Cholecystectomy
Surgical Instruments
Ligation
Metals
Confidence Intervals
Intention to Treat Analysis
Incidence
Common Bile Duct
Bile Ducts
Bile
MEDLINE
Sample Size
Libraries
Randomized Controlled Trials
Odds Ratio
Morbidity
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Methods of cystic duct occlusion during laparoscopic cholecystectomy. / Gurusamy, Kurinchi Selvan; Bong, Jin J.; Fusai, Giuseppe; Davidson, Brian R.

In: Cochrane database of systematic reviews (Online), No. 10, 2010.

Research output: Contribution to journalArticle

Gurusamy, Kurinchi Selvan ; Bong, Jin J. ; Fusai, Giuseppe ; Davidson, Brian R. / Methods of cystic duct occlusion during laparoscopic cholecystectomy. In: Cochrane database of systematic reviews (Online). 2010 ; No. 10.
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