Metastatic bone disease secondary to bronchial adenocarcinoma in a patient with paget’s disease of the bone

Kim Piow Lim, Wei Hao Kok, Nor Azmi Kamaruddin

Research output: Contribution to journalArticle

Abstract

A 69-year-old female complained of intermittent left hip pain for the past 3 years. Biochemical tests revealed normal serum calcium and phosphorus with markedly raised alkaline phosphatase. MRI of the hip revealed extensive marrow signal abnormalities at the left pelvic bone, while CT of the thorax revealed a spiculated lung nodule at the left lower lung lobe. In order to diagnose either primary, metastatic bone tumour or Paget’s disease of the bone (PDB), an open biopsy of the left iliac bone was performed. The histopathology of bone biopsy of the left iliac bone was consistent with PDB. A CT guided biopsy of the lung mass done later revealed adenocarcinoma of the lung. She had18 F-FDG PET-CECT Scan for staging evaluation and result was suggestive of new bony metastases. Patient was started on IV Zoledronic acid for treatment of the PDB. In view of the stage 4 lung adenocarcinoma with bony metastases, patient was scheduled for palliative chemotherapy.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalJournal of the ASEAN Federation of Endocrine Societies
Volume33
Issue number1
DOIs
Publication statusPublished - 1 May 2018

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Osteitis Deformans
Bone Diseases
Adenocarcinoma
Bone and Bones
zoledronic acid
Biopsy
Lung
Hip
Pelvic Bones
Neoplasm Metastasis
Positron-Emission Tomography
Phosphorus
Alkaline Phosphatase
Thorax
Bone Marrow
Calcium
Drug Therapy
Pain
Serum
Neoplasms

Keywords

  • Bronchial adenocarcinoma
  • Metastatic bone disease
  • Paget’s disease of the bone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Metastatic bone disease secondary to bronchial adenocarcinoma in a patient with paget’s disease of the bone. / Lim, Kim Piow; Kok, Wei Hao; Kamaruddin, Nor Azmi.

In: Journal of the ASEAN Federation of Endocrine Societies, Vol. 33, No. 1, 01.05.2018, p. 63-68.

Research output: Contribution to journalArticle

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