Metastasis within a metastasis to the thyroid

A rare phenomenon

Research output: Contribution to journalArticle

Abstract

Metastatic disease involving the thyroid gland is uncommon. Solitary thyroid metastases from various primary sites particularly kidney, lung, and breast had been previously described. To the best of our knowledge, metastases from two topographically separate primary malignancies to the thyroid have never been documented hitherto. This is the first reported case of cancer-to-cancer metastasis involving an invasive breast carcinoma metastasized within a metastatic renal cell carcinoma in the nonneoplastic thyroid in a 58-year-old woman. Distinguishing a secondary thyroid metastases from a primary thyroid malignancy is utmost crucial as treatment differs. The possibility of tumor metastases from two separated primaries should always be considered in a tumor exhibiting malignant cell populations with two distinctive histomorphological appearances. The role of immunohistochemistry stains in equivocal cases cannot be overemphasized.

Original languageEnglish
Pages (from-to)430-432
Number of pages3
JournalIndian Journal of Pathology and Microbiology
Volume60
Issue number3
DOIs
Publication statusPublished - 1 Jul 2017

Fingerprint

Thyroid Gland
Neoplasm Metastasis
Neoplasms
Renal Cell Carcinoma
Breast
Coloring Agents
Immunohistochemistry
Breast Neoplasms
Kidney
Lung
Population
Therapeutics

Keywords

  • Cancer-to-cancer metastases
  • Clear cell renal cell carcinoma
  • Invasive breast carcinoma
  • Thyroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)

Cite this

Metastasis within a metastasis to the thyroid : A rare phenomenon. / Yin Ping, Wong; Affandi, Khairunisa; Tan, Geok Chin; Muhammad, Rohaizak.

In: Indian Journal of Pathology and Microbiology, Vol. 60, No. 3, 01.07.2017, p. 430-432.

Research output: Contribution to journalArticle

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