Metastasis to the sinonasal tract from sigmoid colon adenocarcinoma

Primuharsa Putra Bin Sabir Husin Athar, Norleza Bte Ahmad Norhan, Lokman Bin Saim, Isa Bin Md Rose, Roszalina Ramli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction: Metastatic adenocarcinoma from the gastrointestinal tract to the sinonasal tract is rare. The histological morphology of this lesion is indistinguishable from the colonic variant of primary sinus adenocarcinoma or intestinal-type adenocarcinoma (ITAC). Clinical Picture: This is a report of a case of metastatic adenocarcinoma of colorectal origin to the paranasal sinuses in a 52-year-old female who was previously treated for adenocarcinoma of the sigmoid colon. A histologic study of the surgical specimen from the sinonasal cavity demonstrated a tumour identical to the patient's prior primary tumour of the colon. The sinonasal neoplastic tissue showed marked positivity for carcinoembryonic antigen and expressed cytokeratin 20, which differentiates metastatic colonic adenocarcinoma from ITAC. Treatment/Outcome: The patient received palliative radiation but died 3 months after the diagnosis. Conclusion: Distinguishing metastatic adenocarcinoma from gastrointestinal tract from ITAC can be difficult. In view of the resemblance, immunohistochemical staining can help in differentiating them. It is important to recognise these as metastatic lesions as the treatment is mainly palliative.

Original languageEnglish
Pages (from-to)788-790
Number of pages3
JournalAnnals of the Academy of Medicine Singapore
Volume37
Issue number9
Publication statusPublished - Sep 2008

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Sigmoid Colon
Adenocarcinoma
Neoplasm Metastasis
Gastrointestinal Tract
Keratin-20
Paranasal Sinuses
Carcinoembryonic Antigen
Neoplasms
Colon
Radiation
Staining and Labeling

Keywords

  • Cytokeratin 20
  • Intestinal-type adenocarcinoma
  • Sinonasal metastatic adenocarcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Athar, P. P. B. S. H., Norhan, N. B. A., Saim, L. B., Rose, I. B. M., & Ramli, R. (2008). Metastasis to the sinonasal tract from sigmoid colon adenocarcinoma. Annals of the Academy of Medicine Singapore, 37(9), 788-790.

Metastasis to the sinonasal tract from sigmoid colon adenocarcinoma. / Athar, Primuharsa Putra Bin Sabir Husin; Norhan, Norleza Bte Ahmad; Saim, Lokman Bin; Rose, Isa Bin Md; Ramli, Roszalina.

In: Annals of the Academy of Medicine Singapore, Vol. 37, No. 9, 09.2008, p. 788-790.

Research output: Contribution to journalArticle

Athar, PPBSH, Norhan, NBA, Saim, LB, Rose, IBM & Ramli, R 2008, 'Metastasis to the sinonasal tract from sigmoid colon adenocarcinoma', Annals of the Academy of Medicine Singapore, vol. 37, no. 9, pp. 788-790.
Athar, Primuharsa Putra Bin Sabir Husin ; Norhan, Norleza Bte Ahmad ; Saim, Lokman Bin ; Rose, Isa Bin Md ; Ramli, Roszalina. / Metastasis to the sinonasal tract from sigmoid colon adenocarcinoma. In: Annals of the Academy of Medicine Singapore. 2008 ; Vol. 37, No. 9. pp. 788-790.
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AU - Ramli, Roszalina

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AB - Introduction: Metastatic adenocarcinoma from the gastrointestinal tract to the sinonasal tract is rare. The histological morphology of this lesion is indistinguishable from the colonic variant of primary sinus adenocarcinoma or intestinal-type adenocarcinoma (ITAC). Clinical Picture: This is a report of a case of metastatic adenocarcinoma of colorectal origin to the paranasal sinuses in a 52-year-old female who was previously treated for adenocarcinoma of the sigmoid colon. A histologic study of the surgical specimen from the sinonasal cavity demonstrated a tumour identical to the patient's prior primary tumour of the colon. The sinonasal neoplastic tissue showed marked positivity for carcinoembryonic antigen and expressed cytokeratin 20, which differentiates metastatic colonic adenocarcinoma from ITAC. Treatment/Outcome: The patient received palliative radiation but died 3 months after the diagnosis. Conclusion: Distinguishing metastatic adenocarcinoma from gastrointestinal tract from ITAC can be difficult. In view of the resemblance, immunohistochemical staining can help in differentiating them. It is important to recognise these as metastatic lesions as the treatment is mainly palliative.

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