Metaproteomic analysis of human gut microbiota: Where are we heading?

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The human gut is home to complex microbial populations that change dynamically in response to various internal and external stimuli. The gut microbiota provides numerous functional benefits that are crucial for human health but in the setting of a disturbed equilibrium, the microbial community can cause deleterious outcomes such as diseases and cancers. Characterization of the functional activities of human gut microbiota is fundamental to understand their roles in human health and disease. Metaproteomics, which refers to the study of the entire protein collection of the microbial community in a given sample is an emerging area of research that provides informative details concerning functional aspects of the microbiota. In this mini review, we present a summary of the progress of metaproteomic analysis for studying the functional role of gut microbiota. This is followed by an overview of the experimental approaches focusing on fecal specimen for metaproteomics and is concluded by a discussion on the challenges and future directions of metaproteomic research.

Original languageEnglish
Article number36
JournalJournal of Biomedical Science
Volume24
Issue number1
DOIs
Publication statusPublished - 12 Jun 2017

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Health
Microbiota
Research
Human Activities
Proteins
Population
Gastrointestinal Microbiome
Neoplasms
Direction compound

Keywords

  • Gut Microbiota
  • Human
  • Metaproteomics
  • Multi-omics
  • Technologies

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Metaproteomic analysis of human gut microbiota : Where are we heading? / Lee, Pey Yee; Chin, Siok Fong; Neoh, Hui Min; A. Jamal, A. Rahman.

In: Journal of Biomedical Science, Vol. 24, No. 1, 36, 12.06.2017.

Research output: Contribution to journalReview article

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