Metabolomics in systems biology

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Over the last decade, metabolomics has continued to grow rapidly and is considered a dynamic technology in envisaging and elucidating complex phenotypes in systems biology area. The advantage of metabolomics compared to other omics technologies such as transcriptomics and proteomics is that these later omics only consider the intermediate steps in the central dogma pathway (mRNA and protein expression). Meanwhile, metabolomics reveals the downstream products of gene and expression of proteins. The most frequently used tools are nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). Some of the common MS-based analyses are gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). These high-throughput instruments play an extremely crucial role in discovery metabolomics to generate data needed for further analysis. In this chapter, the concept of metabolomics in the context of systems biology is discussed and provides examples of its application in human disease studies, plant responses towards stress and abiotic resistance and also microbial metabolomics for biotechnology applications. Lastly, a few case studies of metabolomics analysis are also presented, for example, investigation of an aromatic herbal plant, Persicaria minor metabolome and microbial metabolomics for metabolic engineering applications.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages51-68
Number of pages18
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1102
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Metabolomics
Systems Biology
Mass spectrometry
Mass Spectrometry
Metabolic engineering
Technology
Metabolic Engineering
Plant Diseases
Metabolome
Liquid chromatography
Biotechnology
Liquid Chromatography
Gas chromatography
Proteomics
Gas Chromatography-Mass Spectrometry
Nuclear magnetic resonance spectroscopy
Proteins
Magnetic Resonance Spectroscopy
Genes
Throughput

Keywords

  • Biomarker discovery
  • Mass spectrometry
  • Metabolic pathway
  • Metabolite profiling
  • Metabonomics
  • Phytochemical analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Baharum, S. N., & Azizan, K. A. (2018). Metabolomics in systems biology. In Advances in Experimental Medicine and Biology (pp. 51-68). (Advances in Experimental Medicine and Biology; Vol. 1102). Springer New York LLC. https://doi.org/10.1007/978-3-319-98758-3_4

Metabolomics in systems biology. / Baharum, Syarul Nataqain; Azizan, Kamalrul Azlan.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 51-68 (Advances in Experimental Medicine and Biology; Vol. 1102).

Research output: Chapter in Book/Report/Conference proceedingChapter

Baharum, SN & Azizan, KA 2018, Metabolomics in systems biology. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1102, Springer New York LLC, pp. 51-68. https://doi.org/10.1007/978-3-319-98758-3_4
Baharum SN, Azizan KA. Metabolomics in systems biology. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 51-68. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-98758-3_4
Baharum, Syarul Nataqain ; Azizan, Kamalrul Azlan. / Metabolomics in systems biology. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 51-68 (Advances in Experimental Medicine and Biology).
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