Metabolomics data of Mitragyna speciosa leaf using LC-ESI-TOF-MS

Rubashiny Veeramohan, Kamalrul Azlan Azizan, Wan Mohd Aizat Wan Kamaruddin, Hoe Han Goh, Sharif Mahsufi Mansor, Nur Sabrina Mohd Yusof, Syarul Nataqain Baharum, Chyan Leong Ng

Research output: Contribution to journalArticle

Abstract

Mitragyna speciosa is a psychoactive plant known as “ketum” in Malaysia and “kratom” in Thailand. This plant is distinctly known to produce two important alkaloids, namely mitragynine (MG) and 7-hydroxymitragynine (7-OH-MG) that can bind to opioid receptors [1]. MG was reported to exhibit antidepressant properties in animal studies [2]. These compounds were also proposed to have the potential to replace opioid analgesics with much lower risks of side effects [3]. To date, there are only over 40 metabolites identified in M. speciosa [4,5]. To obtain a more complete profile of secondary metabolites in ketum, we performed metabolomics study using mature leaves of the green M. speciosa variety. The leaf samples were extracted using methanol prior to liquid chromatography-electrospray ionization-time of flight-mass spectrometry (LC-ESI-TOF-MS) analysis. This data can be useful to for the identification of unknown metabolites that are associated with alkaloid biosynthesis pathway in M. speciosa.

Original languageEnglish
Pages (from-to)1212-1216
Number of pages5
JournalData in Brief
Volume18
DOIs
Publication statusPublished - 1 Jun 2018

Fingerprint

Mitragyna speciosa
metabolomics
narcotics
leaves
alkaloids
metabolites
antidepressants
Malaysia
ionization
secondary metabolites
liquid chromatography
Thailand
methanol
adverse effects
biosynthesis
mass spectrometry
receptors
animals

Keywords

  • Alkaloids
  • LC–MS
  • Metabolomics
  • Methanolic extraction
  • Mitragyna speciosa

ASJC Scopus subject areas

  • General

Cite this

Metabolomics data of Mitragyna speciosa leaf using LC-ESI-TOF-MS. / Veeramohan, Rubashiny; Azizan, Kamalrul Azlan; Wan Kamaruddin, Wan Mohd Aizat; Goh, Hoe Han; Mansor, Sharif Mahsufi; Yusof, Nur Sabrina Mohd; Baharum, Syarul Nataqain; Ng, Chyan Leong.

In: Data in Brief, Vol. 18, 01.06.2018, p. 1212-1216.

Research output: Contribution to journalArticle

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