Metabolic Syndrome and Its Effect on the Brain: Possible Mechanism

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND & OBJECTIVE: Metabolic syndrome (MetS) is an interconnected group of physiological, biochemical, clinical and metabolic factors that directly increase the risk of cardiovascular disease, type 2 diabetes mellitus (T2DM) and mortality. Rising evidence suggests that MetS plays a significant role in the progression of Alzheimer's disease and other neurodegenerative diseases. Nonetheless, the factors linking this association has not yet been elucidated. As we are facing an increasing incidence of obesity and T2DM in all stages of life, understanding the association of MetS and neurodegenerative diseases is crucial to lessen the burden of the disease.

CONCLUSION: In this review, we will discuss the possible mechanisms which may relate the association between MetS and cognitive decline which include vascular damages, elevation of reactive oxygen species (ROS), insulin resistance and low-grade inflammation.

Original languageEnglish
Pages (from-to)595-603
Number of pages9
JournalCNS & neurological disorders drug targets
Volume17
Issue number8
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Brain
Neurodegenerative Diseases
Type 2 Diabetes Mellitus
Metabolic Diseases
Blood Vessels
Insulin Resistance
Reactive Oxygen Species
Alzheimer Disease
Cardiovascular Diseases
Obesity
Inflammation
Mortality
Incidence
Cognitive Dysfunction

Keywords

  • brain effect
  • diagnosis
  • insulin resistance
  • International Diabetic Federation (IDF)
  • Metabolic syndrome
  • possible pathology.

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

Cite this

Metabolic Syndrome and Its Effect on the Brain : Possible Mechanism. / Arshad, Nurul Ain; Teoh, Seong Lin; Yahaya, Mohamad Fairuz.

In: CNS & neurological disorders drug targets, Vol. 17, No. 8, 01.01.2018, p. 595-603.

Research output: Contribution to journalArticle

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