Metabolic Abnormalities in HIV-Infected Populations without or with Antiretroviral Therapy (ART)

Nazisa Hejazi, Roslee Rajikan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Irregularities in blood metabolic parameters have been detected in the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) era prior to and during the period of treatment with HIV medications. Serum lipids and glucose concentrations, which are highly prevalent metabolic abnormalities, have been affected unfavorably in different patterns. Low concentrations of serum cholesterol and high-density lipoprotein cholesterol (HDL-c) are typically manifested during infection with HIV, whereas increased levels of serum triglycerides (TG), cholesterol, and glucose are well-known metabolic disorders seen during therapy for advanced HIV. In general, serum lipids and glucose disorders are more common and severe with some HIV medicines, which play significant roles in these metabolic complications. Based on the availability of various HIV medicines, the mechanism and pathway, occurrence rate, and severity may be dissimilar for each class of HIV medicine. This chapter introduces and explicates the findings of studies on HIV-associated metabolic abnormalities without and with antiretroviral therapy (ART) in detail.

Original languageEnglish
Title of host publicationHealth of HIV Infected People: Food, Nutrition and Lifestyle with Antiretroviral Drugs
PublisherElsevier Inc.
Pages17-49
Number of pages33
Volume1
ISBN (Print)9780128011430, 9780128007693
DOIs
Publication statusPublished - 1 Jun 2015

Fingerprint

HIV
Population
Serum
Glucose
Therapeutics
Cholesterol
Lipids
HDL Cholesterol
HIV Infections
Acquired Immunodeficiency Syndrome
Triglycerides
Medicine

Keywords

  • Antiretroviral therapy
  • Diabetes
  • Dyslipidemia
  • Glucose intolerance
  • Highly active antiretroviral therapy
  • HIV
  • Metabolic abnormalities
  • Non-nucleoside reverse-transcriptase inhibitors
  • Nucleoside reverse-transcriptase inhibitors
  • Protease inhibitors

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Hejazi, N., & Rajikan, R. (2015). Metabolic Abnormalities in HIV-Infected Populations without or with Antiretroviral Therapy (ART). In Health of HIV Infected People: Food, Nutrition and Lifestyle with Antiretroviral Drugs (Vol. 1, pp. 17-49). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800769-3.00002-0

Metabolic Abnormalities in HIV-Infected Populations without or with Antiretroviral Therapy (ART). / Hejazi, Nazisa; Rajikan, Roslee.

Health of HIV Infected People: Food, Nutrition and Lifestyle with Antiretroviral Drugs. Vol. 1 Elsevier Inc., 2015. p. 17-49.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hejazi, N & Rajikan, R 2015, Metabolic Abnormalities in HIV-Infected Populations without or with Antiretroviral Therapy (ART). in Health of HIV Infected People: Food, Nutrition and Lifestyle with Antiretroviral Drugs. vol. 1, Elsevier Inc., pp. 17-49. https://doi.org/10.1016/B978-0-12-800769-3.00002-0
Hejazi N, Rajikan R. Metabolic Abnormalities in HIV-Infected Populations without or with Antiretroviral Therapy (ART). In Health of HIV Infected People: Food, Nutrition and Lifestyle with Antiretroviral Drugs. Vol. 1. Elsevier Inc. 2015. p. 17-49 https://doi.org/10.1016/B978-0-12-800769-3.00002-0
Hejazi, Nazisa ; Rajikan, Roslee. / Metabolic Abnormalities in HIV-Infected Populations without or with Antiretroviral Therapy (ART). Health of HIV Infected People: Food, Nutrition and Lifestyle with Antiretroviral Drugs. Vol. 1 Elsevier Inc., 2015. pp. 17-49
@inbook{95bd3e48699c4272b99d0ddcbde94a01,
title = "Metabolic Abnormalities in HIV-Infected Populations without or with Antiretroviral Therapy (ART)",
abstract = "Irregularities in blood metabolic parameters have been detected in the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) era prior to and during the period of treatment with HIV medications. Serum lipids and glucose concentrations, which are highly prevalent metabolic abnormalities, have been affected unfavorably in different patterns. Low concentrations of serum cholesterol and high-density lipoprotein cholesterol (HDL-c) are typically manifested during infection with HIV, whereas increased levels of serum triglycerides (TG), cholesterol, and glucose are well-known metabolic disorders seen during therapy for advanced HIV. In general, serum lipids and glucose disorders are more common and severe with some HIV medicines, which play significant roles in these metabolic complications. Based on the availability of various HIV medicines, the mechanism and pathway, occurrence rate, and severity may be dissimilar for each class of HIV medicine. This chapter introduces and explicates the findings of studies on HIV-associated metabolic abnormalities without and with antiretroviral therapy (ART) in detail.",
keywords = "Antiretroviral therapy, Diabetes, Dyslipidemia, Glucose intolerance, Highly active antiretroviral therapy, HIV, Metabolic abnormalities, Non-nucleoside reverse-transcriptase inhibitors, Nucleoside reverse-transcriptase inhibitors, Protease inhibitors",
author = "Nazisa Hejazi and Roslee Rajikan",
year = "2015",
month = "6",
day = "1",
doi = "10.1016/B978-0-12-800769-3.00002-0",
language = "English",
isbn = "9780128011430",
volume = "1",
pages = "17--49",
booktitle = "Health of HIV Infected People: Food, Nutrition and Lifestyle with Antiretroviral Drugs",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Metabolic Abnormalities in HIV-Infected Populations without or with Antiretroviral Therapy (ART)

AU - Hejazi, Nazisa

AU - Rajikan, Roslee

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Irregularities in blood metabolic parameters have been detected in the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) era prior to and during the period of treatment with HIV medications. Serum lipids and glucose concentrations, which are highly prevalent metabolic abnormalities, have been affected unfavorably in different patterns. Low concentrations of serum cholesterol and high-density lipoprotein cholesterol (HDL-c) are typically manifested during infection with HIV, whereas increased levels of serum triglycerides (TG), cholesterol, and glucose are well-known metabolic disorders seen during therapy for advanced HIV. In general, serum lipids and glucose disorders are more common and severe with some HIV medicines, which play significant roles in these metabolic complications. Based on the availability of various HIV medicines, the mechanism and pathway, occurrence rate, and severity may be dissimilar for each class of HIV medicine. This chapter introduces and explicates the findings of studies on HIV-associated metabolic abnormalities without and with antiretroviral therapy (ART) in detail.

AB - Irregularities in blood metabolic parameters have been detected in the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) era prior to and during the period of treatment with HIV medications. Serum lipids and glucose concentrations, which are highly prevalent metabolic abnormalities, have been affected unfavorably in different patterns. Low concentrations of serum cholesterol and high-density lipoprotein cholesterol (HDL-c) are typically manifested during infection with HIV, whereas increased levels of serum triglycerides (TG), cholesterol, and glucose are well-known metabolic disorders seen during therapy for advanced HIV. In general, serum lipids and glucose disorders are more common and severe with some HIV medicines, which play significant roles in these metabolic complications. Based on the availability of various HIV medicines, the mechanism and pathway, occurrence rate, and severity may be dissimilar for each class of HIV medicine. This chapter introduces and explicates the findings of studies on HIV-associated metabolic abnormalities without and with antiretroviral therapy (ART) in detail.

KW - Antiretroviral therapy

KW - Diabetes

KW - Dyslipidemia

KW - Glucose intolerance

KW - Highly active antiretroviral therapy

KW - HIV

KW - Metabolic abnormalities

KW - Non-nucleoside reverse-transcriptase inhibitors

KW - Nucleoside reverse-transcriptase inhibitors

KW - Protease inhibitors

UR - http://www.scopus.com/inward/record.url?scp=84940012938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940012938&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-800769-3.00002-0

DO - 10.1016/B978-0-12-800769-3.00002-0

M3 - Chapter

SN - 9780128011430

SN - 9780128007693

VL - 1

SP - 17

EP - 49

BT - Health of HIV Infected People: Food, Nutrition and Lifestyle with Antiretroviral Drugs

PB - Elsevier Inc.

ER -