Mesosomes are a definite event in antibiotic-treated Staphylococcus aureus ATCC 25923.

L. Santhana Raj, Hiang Lian Hing, Baharudin Omar, Z. Teh Hamidah, R. Aida Suhana, C. P. Nor Asiha, B. Vimala, S. Paramsarvaran, G. Sumarni, K. Hanjeet

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Mesosomes of Staphylococcus aureus ATCC 25923 treated with antibiotics were examined morphologically under the electron microscope. The Transmission Electron Microscope Rapid Method was used to eliminate the artifacts due to sample processing. Mesosomes were seen in all the antibiotic treated bacteria and not in the control group. The main factor that contributes to the formation of mesosomes in the bacteria was the mode of action of the antibiotics. The continuous cytoplasmic membrane with infolding (mesosomes) as in the S. aureus ATCC 25923 is therefore confirmed as a definite pattern of membrane organization in gram positive bacteria assaulted by amikacin, gentamicin, ciprofloxacin, vancomycin and oxacillin antibiotics. Our preliminary results show oxacillin and vancomycin treated bacteria seemed to have deeper and more mesosomes than those treated with amikacin, gentamicin and ciprofloxacin. Further research is needed to ascertain whether the deep invagination and the number of mesosomes formed is associated with the types of antibiotic used.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalTropical Biomedicine
Volume24
Issue number1
Publication statusPublished - Jun 2007

Fingerprint

Staphylococcus aureus
Anti-Bacterial Agents
Oxacillin
Amikacin
Vancomycin
Ciprofloxacin
Gentamicins
Bacteria
Electrons
Gram-Positive Bacteria
Artifacts
Cell Membrane
Control Groups
Membranes
Research

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Santhana Raj, L., Hing, H. L., Omar, B., Teh Hamidah, Z., Aida Suhana, R., Nor Asiha, C. P., ... Hanjeet, K. (2007). Mesosomes are a definite event in antibiotic-treated Staphylococcus aureus ATCC 25923. Tropical Biomedicine, 24(1), 105-109.

Mesosomes are a definite event in antibiotic-treated Staphylococcus aureus ATCC 25923. / Santhana Raj, L.; Hing, Hiang Lian; Omar, Baharudin; Teh Hamidah, Z.; Aida Suhana, R.; Nor Asiha, C. P.; Vimala, B.; Paramsarvaran, S.; Sumarni, G.; Hanjeet, K.

In: Tropical Biomedicine, Vol. 24, No. 1, 06.2007, p. 105-109.

Research output: Contribution to journalArticle

Santhana Raj, L, Hing, HL, Omar, B, Teh Hamidah, Z, Aida Suhana, R, Nor Asiha, CP, Vimala, B, Paramsarvaran, S, Sumarni, G & Hanjeet, K 2007, 'Mesosomes are a definite event in antibiotic-treated Staphylococcus aureus ATCC 25923.', Tropical Biomedicine, vol. 24, no. 1, pp. 105-109.
Santhana Raj L, Hing HL, Omar B, Teh Hamidah Z, Aida Suhana R, Nor Asiha CP et al. Mesosomes are a definite event in antibiotic-treated Staphylococcus aureus ATCC 25923. Tropical Biomedicine. 2007 Jun;24(1):105-109.
Santhana Raj, L. ; Hing, Hiang Lian ; Omar, Baharudin ; Teh Hamidah, Z. ; Aida Suhana, R. ; Nor Asiha, C. P. ; Vimala, B. ; Paramsarvaran, S. ; Sumarni, G. ; Hanjeet, K. / Mesosomes are a definite event in antibiotic-treated Staphylococcus aureus ATCC 25923. In: Tropical Biomedicine. 2007 ; Vol. 24, No. 1. pp. 105-109.
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